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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
CD34+ dermal dendritic cells and mucin deposition in dermatomyositis
Emi Yokoyama, Yoshitaka Nakamura, Tomoko Okita, Nobuyuki Nagai, Masahiko Muto, Department of Dermatology, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-0855, Japan
Author contributions: All the authors fully contributed to the preparation of this manuscript.
Supported by A research grant from the Japan Society for the Promotion of Science (25461695 to Masahiko Muto); and by a grant for Research on Measures for Intractable Diseases (to Masahiko Muto) from the Ministry of Health, Labour and Welfare, Japan.
Conflict-of-interest statement: We have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Masahiko Muto, MD, Professor, Chief, Department of Dermatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami- Kogushi, Ube, Yamaguchi 755-0855, Japan. mmuto@yamaguchi-u.ac.jp
Telephone: +81-836-222269 Fax: +81-836-222269
Received: October 27, 2015
Peer-review started: November 1, 2015
First decision: November 30, 2015
Revised: December 19, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 2, 2016
Processing time: 180 Days and 17.5 Hours
Peer-review started: November 1, 2015
First decision: November 30, 2015
Revised: December 19, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 2, 2016
Processing time: 180 Days and 17.5 Hours
Core Tip
Core tip: Immunohistochemical analysis of skin biopsy specimens with dermatomyositis showed the involvement of CD34+ dermal dendritic cells, α-smooth muscle actin+ myofibroblasts and possibly mast cells, as well as vimentin+ fibroblasts for abnormally dermal mucin production. Further pathophysiological studies are required to more precisely clarify secondary cutaneous mucin deposition by CD34+ dermal dendritic cells. CD34+ dermal dendritic cells and mast cells might be important in giving rise to deposition of dermal mucin in dermatomyositis.