Significant quality of life improvement following total knee replacement for end-stage osteoarthritis: Retrospective cohort study

doi:10.5312/wjo.v17.i3.115537

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Mar 18, 2026 (publication date) through Mar 18, 2026

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Orthop. Mar 18, 2026; 17(3): 115537
Published online Mar 18, 2026. doi: 10.5312/wjo.v17.i3.115537

Table 1 Comparison of baseline demographics and EuroQol five-dimension, five-level questionnaire scores, n (%)

Characteristic	TKR group (n = 480)	Conservative group (n = 400)	P value
Age (years), mean ± SD	65.4 ± 8.2	64.9 ± 7.8	0.34
Gender (female)	312 (65)	252 (63)	0.52
BMI (kg/m²), mean ± SD	32.1 ± 4.5	31.8 ± 4.2	0.39
Kellgren-Lawrence grade
Grade III	288 (60)	240 (60)	0.98
Grade IV	192 (40)	160 (40)	0.98
EQ-5D-5 L score
Baseline, mean ± SD	0.35 ± 0.08	0.36 ± 0.07	0.21
12-Month, mean ± SD	0.76 ± 0.09	0.42 ± 0.08	< 0.001
Mean change (Δ)	+0.41 (95%CI: 0.39-0.43)	+0.06 (95%CI: 0.04-0.08)	< 0.001

TKR: Total knee replacement; BMI: Body mass index; EQ-5D-5 L: EuroQol five-dimension, five-level questionnaire; CI: Confidence interval.

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Citation: Abushal MH, Embaby OM, Mersal M, Badghish E, Elalfy M. Significant quality of life improvement following total knee replacement for end-stage osteoarthritis: Retrospective cohort study. World J Orthop 2026; 17(3): 115537
URL: https://www.wjgnet.com/2218-5836/full/v17/i3/115537.htm
DOI: https://dx.doi.org/10.5312/wjo.v17.i3.115537