Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2026; 17(2): 113667
Published online Feb 18, 2026. doi: 10.5312/wjo.v17.i2.113667
Published online Feb 18, 2026. doi: 10.5312/wjo.v17.i2.113667
Value of “true” leukocytosis formula in determining total knee arthroplasty prosthetic joint infection in the community hospital setting
Brendan M Sweeney, Shaan Sadhwani, Timothy Edwards, Department of Orthopedic Surgery, University of Pittsburgh Medical Center of Central PA, Harrisburg, PA 17109, United States
Matthew Kelly, Department of Orthopedic Surgery, Orthopedic Institute of PA, Harrisburg, PA 17109, United States
Co-corresponding authors: Brendan M Sweeney and Shaan Sadhwani.
Author contributions: Sweeney BM designed the research study; Sweeney BM, Edwards T performed data collection; Sadhwani S and Edwards T performed data analysis; Sweeney BM, Sadhwani S, Edwards T, and Kelly M performed manuscript editing and writing; Sweeney BM and Sadhwani S contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript.
Institutional review board statement: This study was performed under the guidance of University of Pittsburgh Medical Center of Central PA Institutional Review Board (approval No. 23E002) and certificate of this will be available upon request.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at sweeneybm4@upmc.edu. All data obtained in accordance with our institutional review board and all data has been anonymized. No additional data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Brendan M Sweeney, Department of Orthopedic Surgery, University of Pittsburgh Medical Center of Central PA, 4300 Londonderry Road, Harrisburg, PA 17109, United States. sweeneybm4@upmc.edu
Received: September 1, 2025
Revised: September 21, 2025
Accepted: December 4, 2025
Published online: February 18, 2026
Processing time: 156 Days and 2.5 Hours
Revised: September 21, 2025
Accepted: December 4, 2025
Published online: February 18, 2026
Processing time: 156 Days and 2.5 Hours
Core Tip
Core Tip: In this study we examine the usefulness of applying a correction formula for synovial fluid aspirations that contain red blood cells when determining prosthetic joint infections (PJI) using the international consensus meeting criteria. We compare the international consensus meeting criteria for PJI score both prior to and after applying the correction formula to evaluate if there would be any change to diagnosis in patients with concern for PJI.