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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Feb 18, 2026; 17(2): 113659
Published online Feb 18, 2026. doi: 10.5312/wjo.v17.i2.113659
Published online Feb 18, 2026. doi: 10.5312/wjo.v17.i2.113659
Effect of teriparatide on improving fracture union in osteoporotic intertrochanteric fractures: A systematic review and meta-analysis
Kumar Keshav, Department of Orthopedics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Kumar Kaustubh, Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Prabhaker Mishra, Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Author contributions: Keshav K designed the research study and wrote the first draft; Keshav K and Kaustubh K searched the eligible studies and extracted the data; Mishra P performed the statistical analysis. All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kumar Keshav, Associate Professor, Department of Orthopedics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Apex Trauma Centre, Vrindavan Yojna, Lucknow 226014, Uttar Pradesh, India. keshav4700@yahoo.co.in
Received: September 1, 2025
Revised: September 22, 2025
Accepted: December 3, 2025
Published online: February 18, 2026
Processing time: 157 Days and 3.7 Hours
Revised: September 22, 2025
Accepted: December 3, 2025
Published online: February 18, 2026
Processing time: 157 Days and 3.7 Hours
Core Tip
Core Tip: This meta-analysis was conducted to determine the effect of subcutaneous injection of teriparatide on the bone union of osteoporotic intertrochanteric fractures. Six studies (four randomized controlled trials and two non-randomized studies) met the inclusion criteria for systematic review. We found in the pooled meta-analysis that teriparatide reduced union time, varus collapse, and complications in osteoporotic intertrochanteric fractures. Future studies including more patients should be undertaken to confirm the results of this meta-analysis.