Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Mar 18, 2025; 16(3): 102520
Published online Mar 18, 2025. doi: 10.5312/wjo.v16.i3.102520
Denosumab regimens in the treatment of giant cell tumor of bone: A systematic review with meta-analysis
Bruno G Barreto, Claudio Santili, Alex Guedes, Fernando D Moreira, Claudio Luiz DSL Paz
Bruno G Barreto, Department of Orthopedics and Traumatology, Hospital Aristides Maltez, Salvador 40285-001, Bahia, Brazil
Bruno G Barreto, Alex Guedes, Fernando D Moreira, Department of Orthopedics and Traumatology, Hospital Santa Izabel, Salvador 40050-410, Bahia, Brazil
Claudio Santili, Department of Orthopedics and Traumatology, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo 01221-020, São Paulo, Brazil
Alex Guedes, Department of Orthopedics and Traumatology Medical Residency Program, Professor Edgard Santos University Hospital Complex, Brazilian Hospital Services Enterprise, Federal University of Bahia, Salvador 40110-060, Bahia, Brazil
Alex Guedes, Department of Orthopedics and Traumatology, Hospital Aristides Maltez, Salvador 400285-001, Bahia, Brazil
Claudio Luiz DSL Paz, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador 40000-000, Bahia, Brazil
Co-corresponding authors: Bruno G Barreto and Alex Guedes.
Author contributions: Barreto BG contributed to the design and conception of the study and the writing of the manuscript; Moreira FD and Paz CLD contributed to acquisition of data and statistical analyses; Barreto BG and Guedes A contributed to the performance and quality of the research; Guedes A and Santili C contributed to final revision and the writing of the manuscript.
Conflict-of-interest statement: All the authors have no financial or non-financial interests to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bruno G Barreto, MD, Professor, Department of Orthopedics and Traumatology, Hospital Aristides Maltez, av. Dom João VI 332, Salvador 40285-001, Bahia, Brazil. bbarreto1978@gmail.com
Received: October 21, 2024
Revised: January 6, 2025
Accepted: February 12, 2025
Published online: March 18, 2025
Processing time: 142 Days and 16.7 Hours
Core Tip

Core Tip: This systematic review with meta-analysis of proportions sought to evaluate the effectiveness of various denosumab-containing therapeutic regimens in the treatment of giant cell tumor of bone in terms of clinical outcomes, imaging response (IR), local recurrence (LR), and adverse events. Denosumab proved to be effective in inducing clinical response and IR, without impact on LR, regardless of the regimen and number of doses.