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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Nov 18, 2025; 16(11): 110426
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.110426
Published online Nov 18, 2025. doi: 10.5312/wjo.v16.i11.110426
Correlation of magnetic resonance imaging biomarkers (tissue bridges) with neurological recovery following traumatic spinal cord injury
Roop Singh, Department of Orthopaedic Surgery, Paraplegia & Rehabilitation, Rohtak 124001, Haryāna, India
Sachin Gautam, Department of Orthopedics, Sharma PGIMS, Rohtak 124001, Haryāna, India
Shalini Aggarwal, Department of Radiodiagnosis, Sharma PGIMS, Rohtak 124001, Haryāna, India
Svareen Kaur, Baba Saheb Ambedkar Medical College, New Delhi 110085, Delhi, India
Mantu Jain, Department of Orthopaedics, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India
Author contributions: Singh R was responsible for conceptualization, methodology, writing the original draft, and revising the draft; Gautam S was responsible for conceptualization, methodology, recruitment, critical inputs, and revising the draft; Aggarwal S was responsible for methodology, recruitment, critical inputs, and revising the draft; Kaur S was responsible for writing the original draft and revision of drafts; Jain M was responsible for writing the original draft and revision of drafts.
Institutional review board statement: Institutional board clearance was taken: IEC- BREC/22/TH/Ortho-08.
Clinical trial registration statement: The registration identification number is CTRI/2023/10/059194.
Informed consent statement: Informed consent was taken for the patients.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other co-authors who contributed their efforts in this manuscript.
Data sharing statement: Consent for data sharing was taken from the patient. The first author has the excel sheet, if needed.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mantu Jain, MD, Additional Professor, Department of Orthopaedics, All India Institute of Medical Sciences Bhubaneswar, Sijua, Bhubaneswar 751019, Odisha, India.
Received: June 7, 2025
Revised: July 9, 2025
Accepted: October 10, 2025
Published online: November 18, 2025
Processing time: 161 Days and 15.9 Hours
Revised: July 9, 2025
Accepted: October 10, 2025
Published online: November 18, 2025
Processing time: 161 Days and 15.9 Hours
Core Tip
Core Tip: This prospective study highlights the prognostic value of magnetic resonance imaging (MRI) biomarkers, particularly tissue bridges, in acute spinal cord injury (SCI). Quantitative MRI parameters, especially midsagittal tissue bridge dimensions assessed at 1 and 6 months, positively correlated with motor and sensory recovery. Conversely, greater spinal canal compromise and lesion size predicted poorer outcomes. These findings underscore the utility of early MRI-based assessment in predicting neurological recovery and guiding management in traumatic SCI.