Yasuda T. Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip. World J Orthop 2025; 16(10): 108992 [DOI: 10.5312/wjo.v16.i10.108992]
Corresponding Author of This Article
Tadashi Yasuda, MD, PhD, Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan. tadyasu@kcho.jp
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Orthopedics
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Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 18, 2025 (publication date) through Oct 29, 2025
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Publication Name
World Journal of Orthopedics
ISSN
2218-5836
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Yasuda T. Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip. World J Orthop 2025; 16(10): 108992 [DOI: 10.5312/wjo.v16.i10.108992]
World J Orthop. Oct 18, 2025; 16(10): 108992 Published online Oct 18, 2025. doi: 10.5312/wjo.v16.i10.108992
Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip
Tadashi Yasuda
Tadashi Yasuda, Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, Kobe 650-0047, Hyogo, Japan
Author contributions: Yasuda T contributed to conceptualization, writing, and reviewing the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tadashi Yasuda, MD, PhD, Department of Orthopaedic Surgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan. tadyasu@kcho.jp
Received: April 28, 2025 Revised: May 26, 2025 Accepted: September 4, 2025 Published online: October 18, 2025 Processing time: 172 Days and 5.3 Hours
Core Tip
Core Tip: Disease progression of rapidly progressive hip osteoarthritis in the early stages may be classified into two distinct types: Chondrolysis with or without subsequent femoral head destruction. Serum matrix metalloproteinase-3 levels and spinopelvic malalignment may be predictive factors for subsequent bone destruction when only joint space narrowing is observed. Cartilage matrix fragments generated by stress concentrations on the hip joint due to spinopelvic malalignment may trigger inflammatory pathways involving cytokine and inflammasome activation, resulting in joint destruction during the initial phase of rapidly progressive hip osteoarthritis. A clear understanding of its pathogenesis is essential for early diagnosis and effective intervention.
