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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. May 18, 2024; 15(5): 400-403
Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.400
Published online May 18, 2024. doi: 10.5312/wjo.v15.i5.400
Autologous peripheral blood-derived orthobiologics: Different types and their effectiveness in managing knee osteoarthritis
Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States
Ashim Gupta, Department of Orthopaedics, South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, United States
Ashim Gupta, Department of Regenerative Medicine, BioIntegrate, Lawrenceville, GA 30043, United States
Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida 201301, India
Vijay Kumar Jain, Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital, Delhi 110001, New Delhi, India
Author contributions: Gupta A conceptualized the study; Gupta A and Jain VK drafted, critically reviewed, and edited the manuscript; All authors approved the final version of the article for publication.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashim Gupta, MS, PhD, MBA, DABRM, FABRM, Founder and CEO, President, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States.
Received: December 18, 2023
Revised: February 26, 2024
Accepted: April 8, 2024
Published online: May 18, 2024
Processing time: 148 Days and 21.3 Hours
Revised: February 26, 2024
Accepted: April 8, 2024
Published online: May 18, 2024
Processing time: 148 Days and 21.3 Hours
Core Tip
Core Tip: This editorial briefly defined various autologous peripheral blood-derived orthobiologics (APBO) being explored and assessed their current state of evidence based on the most recently published clinical study for the management of knee osteoarthritis (OA). The present literature demonstrates the potential of these APBOs in reducing pain and improving function in knee OA patients; thus, they can be utilized in patients who are refractory to conservative treatment modalities. Yet, more adequately powered clinical trials with longer follow-up and comparative studies are required to establish the long-term efficacy and determine the most optimal APBO for the management of knee OA, respectively.