Dudun AA, Bonartseva GA, Bonartsev AP. Alginate-based biomaterials in orthopedics: What are the prospects for bacterial alginate? World J Orthop 2025; 16(10): 110562 [DOI: 10.5312/wjo.v16.i10.110562]
Corresponding Author of This Article
Anton P Bonartsev, PhD, Associate Professor, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1, Bld 12, Moscow 119234, Russia. ant_bonar@mail.ru
Research Domain of This Article
Orthopedics
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 18, 2025 (publication date) through Oct 26, 2025
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Publication Name
World Journal of Orthopedics
ISSN
2218-5836
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Dudun AA, Bonartseva GA, Bonartsev AP. Alginate-based biomaterials in orthopedics: What are the prospects for bacterial alginate? World J Orthop 2025; 16(10): 110562 [DOI: 10.5312/wjo.v16.i10.110562]
World J Orthop. Oct 18, 2025; 16(10): 110562 Published online Oct 18, 2025. doi: 10.5312/wjo.v16.i10.110562
Alginate-based biomaterials in orthopedics: What are the prospects for bacterial alginate?
Andrei A Dudun, Garina A Bonartseva, Anton P Bonartsev
Andrei A Dudun, Garina A Bonartseva, A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia
Andrei A Dudun, N.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow 123098, Russia
Anton P Bonartsev, Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow 119234, Russia
Author contributions: Dudun AA wrote the manuscript; Bonartsev AP reviewed and edited the manuscript; and Bonartseva GA designed the research study and approved the final manuscript. All authors have read and approved the final manuscript.
Supported by Russian Science Foundation, No. 23-74-10027.
Conflict-of-interest statement: Bonartsev AP reports grants from Russian Science Foundation, during the conduct of the study; grants from NF Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, outside the submitted work.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anton P Bonartsev, PhD, Associate Professor, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1, Bld 12, Moscow 119234, Russia. ant_bonar@mail.ru
Received: June 11, 2025 Revised: July 1, 2025 Accepted: September 9, 2025 Published online: October 18, 2025 Processing time: 128 Days and 16.3 Hours
Abstract
The mini-review explores the potential use of alginates produced biotechnologically by bacteria for the development of various implantable biomaterials intended for bone and cartilage tissue regeneration in orthopedics: the recent studies on the use of algal alginate-based biomaterials in the form of hydrogels, scaffolds, and microparticles for medical applications are considered as a potential opportunity to use bacterial alginate for these applications, taking into account the advantages of biotechnological production of a polymer with desired properties. The methods of producing different alginate-based biomaterials, the manufacturing of implantable medical devices using them, and the surgical techniques for bone and cartilage tissue regeneration using these materials for orthopedic purposes are discussed.
Core Tip: The mini-review explores the potential use of alginates produced biotechnologically by bacteria of genus Azotobacter and Pseudomonas for the development of various implantable hydrogel biomaterials intended for bone and cartilage tissue regeneration and wound healing in orthopedics.
