Nogueira DMB, Rosso MPO, Buchaim DV, Zangrando MSR, Buchaim RL. Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine. World J Orthop 2024; 15(3): 204-214 [PMID: 38596193 DOI: 10.5312/wjo.v15.i3.204]
Corresponding Author of This Article
Rogério Leone Buchaim, PhD, Associate Professor, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla 9-75, Bauru 17012-901, Brazil. rogerio@fob.usp.br
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Mar 18, 2024; 15(3): 204-214 Published online Mar 18, 2024. doi: 10.5312/wjo.v15.i3.204
Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine
Dayane Maria Braz Nogueira, Marcelie Priscila de Oliveira Rosso, Daniela Vieira Buchaim, Mariana Schutzer Ragghianti Zangrando, Rogério Leone Buchaim
Dayane Maria Braz Nogueira, Mariana Schutzer Ragghianti Zangrando, Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil
Marcelie Priscila de Oliveira Rosso, Rogério Leone Buchaim, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil
Daniela Vieira Buchaim, Medical School, University Center of Adamantina, Adamantina 17800-000, Brazil
Daniela Vieira Buchaim, Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marília, Marília 17525-902, Brazil
Author contributions: Nogueira DMB and Rosso MPO contributed equally to this work; Buchaim DV and Buchaim RL designed the research study; Nogueira DMB and Rosso MPO performed the research; Zangrando analyzed the data; Nogueira DMB, Rosso MPO and Buchaim RL wrote the manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rogério Leone Buchaim, PhD, Associate Professor, Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla 9-75, Bauru 17012-901, Brazil. rogerio@fob.usp.br
Received: November 16, 2023 Peer-review started: November 16, 2023 First decision: December 29, 2023 Revised: January 15, 2024 Accepted: February 1, 2024 Article in press: February 1, 2024 Published online: March 18, 2024 Processing time: 119 Days and 14.8 Hours
Abstract
Bone regeneration is a critical area in regenerative medicine, particularly in orthopedics, demanding effective biomedical materials for treating bone defects. 45S5 bioactive glass (45S5 BG) is a promising material because of its osteoconductive and bioactive properties. As research in this field continues to advance, keeping up-to-date on the latest and most successful applications of this material is imperative. To achieve this, we conducted a comprehensive search on PubMed/MEDLINE, focusing on English articles published in the last decade. Our search used the keywords “bioglass 45S5 AND bone defect” in combination. We found 27 articles, and after applying the inclusion criteria, we selected 15 studies for detailed examination. Most of these studies compared 45S5 BG with other cement or scaffold materials. These comparisons demonstrate that the addition of various composites enhances cellular biocompatibility, as evidenced by the cells and their osteogenic potential. Moreover, the use of 45S5 BG is enhanced by its antimicrobial properties, opening avenues for additional investigations and applications of this biomaterial.
Core Tip: Regenerative medicine demands materials with effective osteoconductive and bioactive properties. Compared with other materials, 45S5 bioactive glass not only exhibits more biocompatibility but also enhances bone growth when combined with composites. Moreover, its antimicrobial properties offer many possibilities for future applications.
