Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes

doi:10.5306/wjco.v9.i7.123

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World Journal of Clinical Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 10, 2018; 9(7): 123-132
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.123

Table 1 Demographic characteristics for the breast cancer and benign pathology groups

	Breast cancer (n = 48)	Benign pathology (n = 26)	P value¹
Mean age (yr)	57.79 ± 14.13 (range: 31-85)	32.54 ± 11.63 (range: 14-60)	0.000
Menarche (yr)	12.42 ± 1.67 (range: 9-16)	12.62 ± 1.69 (range: 9-17)	0.763
Term pregnancy	2.63 ± 2.27 (range: 0-11)	1.50 ± 1.55 (range: 0-5)	0.066
Sexual partners	1.98 ± 1.15 (range: 0-5)	1.76 ± 1.09 (range: 1-3)	0.750
Oral contraceptives	47.92%	65.38%	0.352
Tobacco	50.00%	11.53%	0.002
Alcohol	47.92%	46.15%	0.678
Breast cancer family history	37.50%	19.23%	0.199

¹Breast cancer group vs benign pathology group.

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Table 2 Mean absolute values for the cellular subsets in the breast cancer and benign pathology groups

	Breast cancer (cel/mm³)	Benign pathology (cel/mm³)	P value¹
TCD3+	1517.95 ± 666.23	1861.68 ± 760.52	0.102
TCD4+	888.73 ± 445.18	974.01 ± 390.17	0.504
TCD8+	551.34 ± 284.35	764.54 ± 431.10	0.048
CD4+/CD8+	1.94 (range: 0.59-6.33)	1.57 (range: 0.64-4.36)	0.271

¹Breast cancer group vs benign pathology group.

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Table 3 Correlations between the breast cancer molecular subtypes and the cellular subtypes

	CD4+ (cel/mm³)	CD8+ (cel/mm³)	NK+ (cel/mm³)
Luminal A	916 ± 358.81	645 ± 299.91	1064 ± 455.61
Luminal B HER2-	877 ± 494.16	544 ± 273.04	1120 ± 818.37
Luminal B HER2+	914 ± 318.73	491 ± 208.07	926 ± 500.35
HER2+	680 ± 444.86	426 ± 319.13	834 ± 836.75
TN	992 ± 568.02	483 ± 214.90	1183 ± 837.52
P value¹	0.842	0.527	0.912

¹Between breast cancer molecular subtypes. TN: Triple negative.

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Table 4 Correlations between the breast cancer HPV status and the cellular subtypes

	HPV+ (n = 14)	HPV- (n = 34)	P value¹
CD3+ (cel/mm³)	1832.12 ± 537.08	1399.56 ± 665.69	0.563
CD4+ (cel/mm³)	1139.92 ± 416.84	796.56 ± 416.84	0.091
CD8+ (cel/mm³)	630.66 ± 271.00	518.58 ± 281.53	0.748
CD4+/CD8+	2.11 (range: 0.71-4.17)	1.88 (range: 0.59-6.33)	0.029
NK+ (cel/mm³)	1350.21 ± 736.79	950.47 ± 634.35	0.082

¹HPV+ vs HPV-. HPV: Human papilloma virus; NK: Natural killer.

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Citation: Fernandes A, Pesci-Feltri A, García-Fleury I, López M, Guida V, De Macedo M, Correnti M. Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes. World J Clin Oncol 2018; 9(7): 123-132
URL: https://www.wjgnet.com/2218-4333/full/v9/i7/123.htm
DOI: https://dx.doi.org/10.5306/wjco.v9.i7.123