©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 10, 2018; 9(7): 123-132
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.123
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.123
Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes
Andreína Fernandes, Marisol De Macedo, María Correnti, Oncology and Hematology Institute, Caracas 1050, Venezuela
Adriana Pesci-Feltri, Isabel García-Fleury, Marco López, Vincent Guida, University Hospital of Caracas, Caracas 1050, Venezuela
Author contributions: Fernandes A and Correnti M designed research and wrote the paper; Fernandes A collected data and samples, analyzed and interpreted the data; De Macedo M analyzed the flow cytometry data; Pesci-Feltri A, García-Fleury I, López M, Guida M conducted the mastectomies.
Supported by FONACIT Project , No. G2005000408 ; and PEII Project , No. 2012001201 .
Institutional review board statement: Approved by Bioethics Committee of the University Hospital of Caracas.
Conflict-of-interest statement: The authors confirm that they do not have any conflict of interest.
Correspondence to: Andreína Fernandes, PhD, Biologist, Assistant Professor, Oncology and Hematology Institute, University City, Minerva Street, Caracas 1050, Venezuela. andreinafernandesb@gmail.com
Telephone: +58-414-2754878 Fax: +58-212-6053815
Received: May 28, 2018
Peer-review started: May 28, 2018
First decision: July 9, 2018
Revised: August 26, 2018
Accepted: October 24, 2018
Article in press: October 24, 2018
Published online: November 10, 2018
Processing time: 165 Days and 5.1 Hours
Peer-review started: May 28, 2018
First decision: July 9, 2018
Revised: August 26, 2018
Accepted: October 24, 2018
Article in press: October 24, 2018
Published online: November 10, 2018
Processing time: 165 Days and 5.1 Hours
Core Tip
Core tip: This work detected the presence of the human papilloma virus (HPV) genome in patients with breast cancer and measured the levels of cellular subsets as predictor factors. The viral genome was found in 25% of breast cancer cases, with the high-risk 18 genotype the most frequent. Luminal A tumors represented 33.33% of the sample. The average level of CD3+, CD4+, CD8+ and NK+ cells was decreased in cancer patients compared to the benign pathology group, while the reverse effect was observed in HPV positive patients.