Concurrent chemoradiation for high-risk prostate cancer

Table 1 Comparison of trials investigating chemoradiation for high-risk prostate cancer

Institution/group	n	Radiation technique	Comp Rx	GI toxicity	GU toxicity	Other toxicity
Continuous infusion 5-fluorouracil
SWOG[29]	30	Whole pelvis if not surgically negative to 45 Gy + 70.2 Gy 3DCRT to prostate	97%	Gr 3: 7% Gr 4: 3%	Gr 3: 3% Gr 4: 3%	Multiple Gr 3: 13% (cumulative)
Daily estramustine phosphate + weekly vincristine
Henry Ford Hospital[36]	65	4-field pelvis to 45 Gy + 65-70 Gy 3DCRT to prostate	71%	Gr 3: 0% Gr 4: 2%	Gr 3: 0% Gr 4: 0%	Leukopenia Gr 3: 2%
MSKCC[37]	27	3DCRT to prostate and SV	85%	Gr 3: 35% Gr 4: 0%	Gr 3: 48% Gr 4: 11%	Hematologic Gr 3: 8% Liver Gr 3: 7%
Daily estramustine phosphate
Wayne State[39]	18	Prostate and SV to 50.4-70.2 Gy via 4-field + 3DCRT to prostate 70.2 Gy	78%	Not reported	Not reported	Leukopenia Gr 3: 12% Venous thrombosis Gr: 6% MI Gr 4: 6%
Weekly docetaxel
UMDNJ[52]	22	3DCRT to prostate to 70.2 Gy	100%	Gr 3: 9% Gr 4: 0%	Gr 3: 0% Gr 4: 0%	No Gr 3 or 4
Europe[53]	50	4-field pelvis to 46 Gy + 70 Gy to prostate and proximal SV via 3DCRT or IMRT	92%	Gr 3: 6% Gr 4: 2%	Gr 3: 4% Gr 4: 0%	MI Gr 4: 2%
St. Peter’s[70]	20	72 Gy delivered via IMRT (no further details)	85%	Gr 3: 0% Gr 4: 0%	Gr 3: 0% Gr 4: 0%	Dypsnea Gr 3: 5% Dehydration Gr 3: 10%
UNC[72]	18	Prostate and proximal SV 78 Gy with IMRT	89%	Gr 3: 11% Gr 4: 0%	Gr 3: 0% Gr 4: 0%	Leukopenia Gr 3: 28% Liver Gr 3: 6%
Medical University of South Carolina[73]	19	Prostate and proximal SV 45 Gy + 77.4 Gy prostate with IMRT	89%	Gr 3: 11% Gr 4: 0%	Gr 3: 0% Gr 4: 0%	Fatigue Gr 3: 11%
Biweekly Paclitaxel
NYU[64]	22	4-field pelvis to 39.6 Gy + 63-73.8 Gy to prostate and proximal SV via 3DCRT	100%	Gr 3: 18% Gr 4: 0%	Gr 3: 0% Gr 4: 0%	No Gr 3 or 4

Comp Rx: Percentage of patients completing all protocol treatment; GI: Gastrointestinal; GU: Genitourinary; Gr: Grade; SV: Seminal vesicles; MI: Myocardial infarction; SWOG: Southwest Oncology Group; MSKCC: Memorial Sloan Kettering Cancer Center; UMDNJ: University of Medicine and Dentistry of New Jersey; UNC: University of North Carolina; NYU: New York University; 3DCRT: Three dimensional conformal radiation therapy; IMRT: Intensity modulated radiation therapy.