Sentinel lymph node mapping of a breast cancer of the vulva: Case report and literature review

Table 1 Clinical presentations of vulvar-breast cancer

Ref.	Year	Age (yr)	Location	Size (cm)	Symptoms and duration	Duration (mo)
Greene[2]	1935	59	Right labia majora	20 × 15	Mass	12
Hendrix et al[14]	1956	58	Right Labia minora	3	Ulcerated mass	84
Guerry et al[6]	1976	62	Right labia minora	1.5	Mass	4
Guercio et al[15]	1984	49	Left labia majora	2	Mass	Unk
Cho et al[16]	1985	70	Right labia majora	3 × 4	Mass	30
Simon et al[17]	1988	60	Right labia majora	2 × 2	Ulcerated mass	36
Rose et al[18]	1990	68	Right labia majora	3.5 × 3.5	Mass	36
Di Bonito et al[19]	1992	46	Right labia majora	1.5	Ulcerated mass	24
Bailey et al[20]	1993	65	Right labia majora	3 × 2	Ulcerated mass	36
Levin et al[21]	1994	62	Left clitorus	2.5	Mass	Unk
Kennedy et al[7]	1997	71	Left labia majora	5	Ulceration and dysuria	1
Irvin et al[4]	1998	64	Left lateral mons	3	Indurated mass	48
Gorisek et al[22]	2000	81	Left labia majora	2 × 3	Ulcerated mass	Unk
Piura et al[23]	2002	69	Left labia majora	3	Ulcerated mas	Unk
Chung-Park et al[24]	2002	47	Right labia minora	2	Ulcerated mass	12
Yin et al[25]	2003	84	Mons	5	Swelling	24
Lopes et al[26]	2006	44	Left vulva	2	Mass	48
Fracchioli et al[27]	2006	57	Left vulva	1	Mass	Unk
North et al[28]	2006	49	Right labia minora and clitoris	1.5	Pain and pressure	Unk
			Left groin	2
Naseer et al[29]	2011	57	Right labia majora	1.5	Non painful lesion	Unk
McMaster[30]	2013	60	Left labia majora	3	Pedunculated ulcerated mass	6
Bogani et al[13]	2013	71	Left labia Majora	4	Painful ulcerated mass	Unk
			Left groin	3

Unk: Unkown.

Table 2 Previously published reports

Ref.	Treatment	Histology	ER	PR	Her2-neu	LN	Status	Follow up (mo)
Greene[2]	None	AC + S	NA	NA	NA	NA	DOD	1
Hendrix et al[14]	Surgery	AC	NA	NA	NA	NA	DOD	4
Guerry et al[6]	Surgery	DC	NA	NA	NA	NA	DOD	24
Guercio et al[15]	Surgery + RT	LO	NA	NA	NA	11/24	NED	36
Cho et al[16]	Surgery + tamoxifen	AC	+	+	NA	2/9	NED	24
Simon et al[17]	Surgery + tamoxifen + cyclophosphamide, adriamycin, 5FU	AC	+	+	NA	3/11	DOD	27
	Recurrence cisplatin/etoposide then carboplatin/etoposide
Rose et al[18]	Surgery + RT + tamoxifen	DC	+	-	NA	1/15	Unk	Unk
Di Bonito et al[19]	Surgery	Unk			NA	11/13	NED	4
Bailey et al[20]	Surgery + tamoxifen	DC	+	+	NA	2/20	NED	12
Levin et al[21]	Surgery + tamoxifen	AC	+	-	+	4/11	NED	24
	Recurrence restarted tamoxifen/RT						NED	12
Kennedy et al[7]	Surgery + adriamycin/cyclophosphamide	Unk	-	-	NA	9/9	NED	15
Irvin et al[4]	Surgery + cytoxan/Mtx/5FU + RT + tamoxifen	AC	+	+	NA	1/14	NED	4
Gorisek et al[22]	Surgery + tamoxifen	AC	+	+	NA	NA	NED	19
Piura et al[23]	Surgery + adriamycin/cyclophosphamide/paclitaxel + RT + tamoxifen	AC	+	+	NA	7/15	NED	14
Chung-Park et al[24]	Surgery	MU	+	+	-	NA	NED	36
Yin et al[25]	Surgery	MU	+	+	-	1/11	NED	9
Lopes et al[26]	Surgery + docetaxel/doxorubicin/cyclophosphamide + tamoxifen	MU	+	NA	-	2/13	Unk	Unk
Fracchioli et al[27]	Surgery + 5FU/adriamycin/cyclophosphamide + tamoxifen	AC	-	NA	NA	7/7	Rec	36
	Recurrence-paclitaxel						Unk	Unk
North et al[28]	Surgery + cyclophosphamide/epirubicin/5FU + weekly docetaxel + tamoxifen	DC	+	+	-	5/7	Unk	Unk
Naseer et al[29]	Surgery + 5FU/epirubicin/cyclophosphamide + weekly docetaxel + RT + aromatase	DC	+	+	-	3/13	Unk	Unk
McMaster et al[30]	Surgery + RT	DC	+	NA	NA	NA	Unk	Unk
Bogani et al[13]	Surgery + epirubicin/cyclophosphamide + tamoxifen	DC	+	+	NA	1/8	NED	24

AC: Adenocarcinoma; DC: Ductal carcinoma; DOD: Dead of disease; LO: Lobular; MU: Mucinous; Mtx: Methotrexate; NA: Not applicable; NED: No evidence of disease; Rec: Recurrence; RT: Radiation therapy; S: Squamous; Unk: Unknown; 5FU: 5-fluoruouracil.