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©The Author(s) 2025.
World J Clin Oncol. Sep 24, 2025; 16(9): 109182
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.109182
Published online Sep 24, 2025. doi: 10.5306/wjco.v16.i9.109182
Table 1 Descriptive statistics and clinical features of the entire study population are summarized, n (%)
| Descriptive and clinical features | |
| Age group, median (IQR) | 44 (10) |
| 21-30 | 5 (3.8) |
| 31-40 | 43 (32.8) |
| 41-50 | 83 (63.4) |
| Sex | |
| Male | 70 (53.4) |
| Female | 61 (46.6) |
| Survey (month), median (IQR) | 44.5 (44.7) |
| Tumor diameter (cm), median (IQR) | 5 (2.5) |
| Multiple colorectal tumor | |
| Negative | 127 (96.9) |
| Positive | 4 (3.1) |
| Right colon and transvers colon | |
| Negative | 81 (60.0) |
| Positive | 54 (40.0) |
| Left colon and sigmoid colon | |
| Negative | 90 (66.6) |
| Positive | 45 (33.3) |
| Rectosigmoid colon and rectum | |
| Negative | 99 (73.3) |
| Positive | 36 (26.6) |
| Differentiation degree | |
| Well and moderately | 106 (81.5) |
| Poor | 24 (18.5) |
| Adenocarcinoma component in the tumor | |
| Negative | 6 (4.6) |
| Positive | 125 (95.4) |
| Musinous component in the tumor | |
| Negative | 92 (70.2) |
| Positive | 39 (29.8) |
| Signet-ring cell carcinoma component in the tumor | |
| Negative | 122 (93.1) |
| Positive | 9 (6.9) |
| Lymphovascular invasion | |
| Negative | 73 (55.7) |
| Positive | 58 (44.3) |
| Perineural invasion | |
| Negative | 90 (68.7) |
| Positive | 41 (31.3) |
| Recurrens1 | |
| Negative | 103 (78.6) |
| Positive | 28 (21.4) |
| 2nd tumor | |
| Negative | 120 (91.6) |
| Positive | 11 (8.4) |
| Family history | |
| Negative | 44 (52.4) |
| Positive | 40 (47.6) |
| LN invasion | |
| Negative | 73 (56.5) |
| Positive | 58 (43.5) |
| T stage | |
| T1 | 1 (0.8) |
| T2 | 9 (6.9) |
| T3 | 81 (61.8) |
| T4a ve T4b | 40 (30.5) |
| N stage | |
| N0 | 64 (48.9) |
| N1a, N1b ve N1c | 40 (30.5) |
| N2a ve N2b | 27 (20.6) |
| Metastasis | |
| Negative | 99 (75.6) |
| Positive | 32 (24.4) |
| Stage | |
| 1 | 8 (6.1) |
| 2 | 48 (37.4) |
| 3 | 43 (32.8) |
| 4 | 32 (23.7) |
| Number of positive LNs, median (IQR) | 0 (3) |
| Number of LNs removed, median (IQR) | 20.5 (17) |
Table 2 Clinicopathological comparisons between the two groups based on microsatellite status determined by immunohistochemistry results, n (%)
| Descriptive and clinical features | Microsatellite instabil | Microsatellite stabile | P value |
| Age group, median (IQR) | 42 (7) | 46 (10) | 0.0351 |
| 21-30 | 0 (0) | 5 (5) | |
| 31-40 | 14 (46.7) | 29 (29) | |
| 41-50 | 16 (53.3) | 66 (66) | |
| Sex | |||
| Male | 21 (70) | 48 (48) | 0.0342 |
| Female | 9 (30) | 52 (52) | |
| Survey (month), median (IQR) | 52 (42.5) | 38 (45) | 0.0201 |
| Right colon and transvers colon | |||
| Negative | 10 (31.2) | 71 (69.6) | < 0.0012 |
| Positive | 22 (68.7) | 31 (30.3) | |
| Rectosigmoid colon and rectum | |||
| Negative | 29 (90.6) | 69 (67.6) | 0.0112 |
| Positive | 3 (9.3) | 33 (29.4) | |
| Musinous component in the tumor | |||
| Negative | 15 (50) | 77 (77) | 0.0042 |
| Positive | 15 (50) | 23 (23) | |
| LN metastasis | |||
| Negative | 22 (73.3) | 51 (51) | 0.0312 |
| Positive | 8 (26.7) | 49 (49) | |
| Number of positive LNs, median (IQR) | 0 (1) | 0 (3) | 0.0311 |
| T stage | - | ||
| T1 | 0 (0) | 1 (1) | |
| T2 | 2 (6.7) | 7 (7) | |
| T3 | 21 (70) | 60 (60) | |
| T4a ve T4b | 7 (23.3) | 32 (32) | |
| N stage | - | ||
| N0 | 21 (70) | 42 (42) | |
| N1a, N1b ve N1c | 6 (20) | 34 (34) | |
| N2a ve N2b | 3 (10) | 24 (24) | |
| Metastasis | |||
| Negative | 28 (93.3) | 70 (70) | 0.0092 |
| Positive | 2 (6.7) | 30 (30) | |
| Stage | 0.0122 | ||
| 1 | 2 (6.7) | 6 (6) | |
| 2 | 18 (60) | 30 (30) | |
| 3 | 8 (26.7) | 35 (35) | |
| 4 | 2 (6.7) | 29 (29) | |
| 2nd tumor | |||
| Negative | 23 (76.7) | 96 (96) | 0.0033 |
| Positive | 7 (23.3) | 4 (4) | |
| Next-Generation Sequencing status | < 0.0013 | ||
| Mutasyon positive | 13 (76.5) | 1 (2.7) | |
| Mutasyon negative | 4 (23.5) | 35 (97.3) |
Table 3 Lynch syndrome patients, detailed information
| Cases | Sex | Age | Location | Immunohistochemistry-mismatch repair | Next-Generation Sequencing | Ex-on | Mutation | Tumor | Family history |
| 1 | Female | 36 | 1 | MSH2/MSH6 | MSH2 | 13 | c.2074G > A p.P316 L | CRC | Multiple CRC and gastric cancer |
| 2 | Male | 43 | 1 | MLH1/PMS2 | MLH1 | 15 | c.1676T > G p.L559R | CRC | Multiple CRC |
| 3 | Female | 38 | 1 | MSH2/MSH6 | MSH2 | 12 | c.1861C > T p.Arg621Ter | CRC, EC | CRC and EC |
| 4 | Male | 46 | 1 ve 1 | MSH2/MSH6 | MSH2 | 12 | c.1799C > T p.A600V | Synchron CRC, urinary tract ca | Father with CRC, mother with EC |
| 5 | Male | 46 | 1 | 0 | MSH6 | 4 | c.2194C > T p.R732* | CRC | Father with CRC, Grandma and 3 aunt with breast cancer |
| 6 | Male | 42 | 1 | MSH2/MSH6 | MSH2 | 1 | c.70C > T p.Gln24Ter | CRC | 0 |
| 7 | Female | 45 | 2 | MSH2/MSH6 | MSH2, MLH1 | 12 1 | c.1861C > T p.Arg621Terc49A > C/p.Asn17His | CRC | Brother, sister and her doughter with CRC |
| 8 | Male | 39 | 1 | PMS2 | PMS2 | 3 | c.182delA p.Y61fs*15 | CRC | Uncle with CRC |
| 9 | Male | 40 | 2 | MLH1/PMS2 | MLH1 | Splice site | c.1990-1G > C | CRC | Father and brother with CRC sister with renal cancer |
| 10 | Male | 40 | 1 | MLH1/PMS2 | MLH1, PMS2 | İntron 17 exon 8 | c.1990-1G > C c1609G > A/p.Glu537 Lys | CRC | Father and brother with CRC sister with renal cancer |
| 11 | Male | 34 | 2 | MSH2/MSH6 | MSH2 | 5 | c.942G > A p.Q314Q | CRC | Father and uncle with CRC |
| 12 | Male | 44 | 2 | MSH2/MSH6 | MSH2 | 12 | C.1927G > T p.E643* | CRC | Father and uncle with gastric cancer |
| 13 | Male | 43 | 1 | MSH2/MSH6 | MSH6 | 4 | c.660A > C p.E220D | CRC, small intestine cancer | Father, uncle and aunt with CRC |
| 14 | Male | 37 | 1 | MSH2/MSH6 | MSH2 | 2 | c.352dupT, p.Y118fs*5 | CRC | 0 |
- Citation: Sür Y, Gür EÖ, Cengiz F, Subaşıoğlu A, Güzeliş İ, Demir S, Sari AA, Haciyanli M, Dilek ON. Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study. World J Clin Oncol 2025; 16(9): 109182
- URL: https://www.wjgnet.com/2218-4333/full/v16/i9/109182.htm
- DOI: https://dx.doi.org/10.5306/wjco.v16.i9.109182
