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Observational Study
Copyright ©The Author(s) 2025.
World J Clin Oncol. Nov 24, 2025; 16(11): 111397
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111397
Table 1 Cancer survivors’ demographics and clinical characteristics (n = 101)
Variable
Category
n1
%
Age (year)61 or more2120.6
56-601716.7
36-401514.7
41-451312.7
46-501110.8
31-351110.8
51-5598.8
26-3011
20-2543.9
GenderMale2827.5
Level of educationBachelor degree5452.9
Post-graduate2928.4
Secondary degree1514.7
Elementary degree32.9
Primary degree11
Marital statusMarried7977.5
Single1211.8
Divorced87.8
Widow32.9
Living statusUrban city9896.1
Village43.9
Is it your house that you live in?Owner6462.7
Rent3837.3
Profession/jobworking5755.9
Retired2726.5
No job1817.6
What is the chronic disease that you suffer from?Hypertension2726.5
Diabetes2625.5
High cholesterol1716.7
Respiratory disease1514.7
Neurological disease87.8
Cardiovascular/heart disease76.9
Kidney/renal disease22
Monthly income (SAR)16000 or more3332.4
1000-50002928.4
11000-150002120.6
6000-100001918.6
Table 2 Univariate analysis of World Health Organization Quality of Life-BREF domain scores by demographic and clinical characteristics among Saudi cancer survivors
Variable
Category
Environment mean
Physical health mean
Psychological mean
Social mean
Environment P value
Physical health P value
Psychological P value
Social P value
Age (year)20-253.663.043.73.920.730.340.210.29
26-302.881.831.62.670.730.340.210.29
31-353.262.973.6230.730.340.210.29
36-403.072.913.493.160.730.340.210.29
41-453.243.093.773.490.730.340.210.29
46-503.192.953.163.150.730.340.210.29
51-553.193.073.533.780.730.340.210.29
56-603.323.173.593.430.730.340.210.29
61 or more3.533.193.713.560.730.340.210.29
GenderFemale3.293.023.543.360.880.340.680.64
Male3.313.143.613.450.880.340.680.64
Is it your house that you live in?Rent3.133.063.633.330.090.910.520.61
Owner3.393.053.523.420.090.910.520.61
Level of educationBachelor degree3.153.023.453.280.210.600.440.17
Elementary degree3.543.113.733.890.210.600.440.17
Post-graduate3.553.163.793.310.210.600.440.17
Primary degree3.53.53.840.210.600.440.17
Secondary degree3.252.943.473.80.210.600.440.17
Living statusUrban city3.323.093.613.430.090.000.000.02
Village2.692.122.452.420.090.000.000.02
Marital statusDivorced3.163.043.183.50.740.050.160.93
Married3.333.123.653.40.740.050.160.93
Single3.252.673.223.280.740.050.160.93
Widow2.922.943.63.220.740.050.160.93
Profession/jobRetired3.443.23.613.420.390.040.280.96
No job3.152.793.293.410.390.040.280.96
Working3.273.073.623.370.390.040.280.96
What is the chronic disease that you suffer from?Cardiovascular/heart disease3.293.13.693.480.800.200.900.92
Cholesterol3.432.853.473.430.800.200.900.92
Diabetes3.153.173.463.450.800.200.900.92
Kidney/renal disease3.123.083.32.830.800.200.900.92
Nuerlogical disease3.192.813.583.50.800.200.900.92
Respiratory disease3.212.913.513.20.800.200.900.92
Hypertension3.443.23.733.40.800.200.900.92
Monthly income (SAR)1000-50003.162.933.273.450.060.280.090.64
11000-150003.13.023.523.170.060.280.090.64
16000 or more3.583.193.733.450.060.280.090.64
6000-100003.233.043.753.420.060.280.090.64
Table 3 Multivariable linear regression of World Health Organization Quality of Life-BREF domain scores by demographic and clinical characteristics among Saudi cancer survivors
PredictorPhysical health
Psychological
Beta
CI lower
CI upper
P value
Beta
CI lower
CI upper
P value
Gender
    Male-0.20-0.520.130.23-0.47-0.93-0.010.04
    Female-1-------
Age (year)
    26-30-1.35-2.58-0.110.03-2.29-4.05-0.530.01
    31-350.00-0.820.821.000.45-0.711.620.44
    36-40-0.16-0.880.560.66-0.11-1.130.900.82
    41-450.07-0.680.820.850.36-0.701.420.50
    46-50-0.13-0.950.680.75-0.14-1.301.020.81
    51-550.03-0.750.820.930.30-0.821.420.60
    56-60-0.02-0.820.790.970.23-0.911.370.69
    61 or more--------
Level of education
    Elementary degree0.02-0.720.760.960.92-0.131.960.08
    Post-graduate0.24-0.140.610.210.51-0.021.040.06
    Primary degree0.17-1.001.330.780.03-1.631.680.97
    Secondary degree--------
Marital status
    Married0.15-0.280.580.490.49-0.121.110.11
    Single0.18-0.530.880.620.97-0.021.970.06
    Widow--------
    Village-1.12-1.84-0.400.00-2.00-3.03-0.980.00
Do you own or rent your current living?
    Own0.01-0.240.260.96-0.23-0.580.130.21
    Rent--------
Employment status-0.44-0.930.040.07-0.41-1.100.270.23
    Unemployed0.13-0.350.610.59-0.45-1.130.240.20
    Full time job--------
Monthly income (SAR)
    11000-150000.14-0.300.580.520.55-0.081.170.08
    16000 or more--------
    6000-100000.15-0.300.590.510.960.331.590.00
Chronic diseases
    Cholesterol-0.12-0.650.410.66-0.26-1.010.500.50
    Diabetes0.13-0.350.610.59-0.45-1.130.240.20
    Kidney/renal disease--------
    Neurological disease-0.12-0.790.550.73-0.47-1.420.490.33
    Respiratory disease-0.19-0.750.370.50-0.48-1.270.310.23
    Hypertension0.15-0.350.640.56-0.25-0.950.450.48
Table 4 Multivariable linear regression of World Health Organization Quality of Life-BREF domain scores by demographic and clinical characteristics among Saudi cancer survivors
PredictorSocial
Environment
Beta
CI lower
CI upper
P value
Beta
CI lower
CI upper
P value
Gender
    Male0.00-0.570.571.00-0.32-0.810.160.19
    Female--------
Age (year)
    26-30-1.23-3.390.930.26-1.13-2.970.710.22
    31-35-0.55-1.990.880.44-0.04-1.271.180.94
    36-40-0.65-1.900.600.31-0.43-1.490.640.43
    41-45-0.27-1.571.040.68-0.04-1.151.070.94
    46-50-0.45-1.870.980.53-0.12-1.341.090.84
    51-55-0.10-1.481.280.89-0.22-1.390.960.71
    56-60-0.38-1.781.020.59-0.20-1.400.990.73
    61 or more--------
Level of education
    Elementary degree1.09-0.202.370.100.51-0.581.610.35
    Post-graduate0.16-0.490.820.620.40-0.160.950.16
    Primary degree0.28-1.752.320.780.17-1.561.910.84
    Secondary degree--------
Marital status
    Married-0.10-0.860.650.790.39-0.251.030.23
    Single0.02-1.211.240.980.76-0.281.810.15
    Widow--------
    Village-1.01-2.270.250.12-1.04-2.120.030.06
Do you own or rent your current living?
    Owner-0.05-0.490.390.820.05-0.320.430.78
    Rent--------
Employment status
    Unemployed0.18-0.671.020.68-0.41-1.130.310.26
    Full time job--------
Monthly income (SAR)
    11000-150000.07-0.700.840.850.24-0.410.900.46
    16000 or more--------
    6000-100000.54-0.241.310.170.47-0.191.130.16
Chronic diseases
    Cholesterol-0.10-1.030.820.830.11-0.680.900.78
    Diabetes-0.22-1.060.620.60-0.17-0.890.540.63
    Kidney/renal disease--------
    Neurological disease-0.33-1.500.840.58-0.17-1.160.830.74
    Respiratory disease-0.48-1.450.490.33-0.33-1.160.500.43
    Hypertension-0.30-1.160.570.500.05-0.690.780.90