Mixed odontogenic tumors: A review of the clinicopathological and molecular features and changes in the WHO classification

Table 1 Reported 45 cases of ameloblastic fibrodentinoma found in the English language literature

Case	Ref.	Year	Sex/age	Location
1	Straith[42]	1936	F/30	Posterior mandible
2	Field and Ackerman[43]	1942	NA/9	Posterior mandible
3	Stafne[44]	1943	F/25	Posterior mandible
4	Stafne[44]	1943	NA/23	Posterior mandible
5	Stafne[45]	1946	NA	NA
6	Thoma and Goldman[46]	1946	M/6	Maxillary sinus area
7	Ingham[47]	1952	F/19	Posterior mandible
8	Sirsat[48]	1952	M/36	Maxillary sinus area
9	Husted and Pindborg[49]	1953	M/4	Anterior maxilla
10	Husted and Pindborg[49]	1953	F/63	Posterior mandible
11	Hitchin and White[50]	1955	M/4	Anterior mandible
12	Pindborg[51]	1955	M/20	Posterior mandible
13	Gorlin et al[52]	1961	F/4	Anterior maxilla
14	Gorlin et al[52]	1961	F/13	Posterior mandible
15	Gorlin et al[52]	1961	M/8	Posterior mandible
16	Azaz et al[53]	1967	M/4.5	Anterior mandible
17	Manning and Browne[54]	1970	F/55	Posterior mandible
18	Hoggins and Browne[55]	1976	M/24	Posterior mandible
19	Gulmen et al[56]	1976	M/30	Anterior mandible
20	Godjesk et al[57]	1980	M/3.5	Anterior mandible
21	Rennie and Critchlow[58]	1981	M/7	Posterior maxilla
22	van Wyk and van der Vyver[59]	1983	M/8	Posterior mandible
23	Villafañe et al[60]	1986	F/22	Posterior maxilla
24	Lukinmaa et al[61]	1897	M/11	Posterior mandible
25	Anker and Radden[62]	1989	F/24	Posterior mandible
26	Ulmansky et al[63]	1994	M/60	Posterior maxilla
27	Ulmansky et al[63]	1994	M/8	Posterior maxilla
28	Cassidy et al[64]	1987	M/12	Posterior maxilla
29	Akal et al[65]	1997	M/9	Posterior mandible
30	Akal et al[65]	1997	M/22	Mandible
31	Takeda et al[66]	2000	M/21	Mandibular retromolar area
32	Karasu et al[67]	2004	F/21	NA
33	Bhargava et al[68]	2011	M/51	Anterior maxilla
34	Giraddi and Garg[9]	2012	F/17	Mandible
35	Bologna-Molina et al[8]	2013	F/1.5	Mandible
36	Sankireddy et al[69]	2013	M/14	Anterior maxilla
37	Salehinejad et al[70]	2013	F/13	Anterior mandible
38	Ikeda et al[71]	2014	F/8	Posterior mandible
39	Lee et al[72]1	2014	F/4	Anterior mandible
40	Unsal et al[73]	2014	M/11	Anterior mandible
41	Joseph et al[74]	2015	M/12	Anterior Maxilla
42	Costa et al[75]	2015	F/12	Posterior mandible
43	Bhargava et al[76]	2016	M/1	Anterior mandible
44	Bavle et al[77]	2017	F/14	Posterior mandible
45	Sabu et al[78]	2018	M/20	Mandible (left body to right parasymphysis)

¹Associated with calcifying cystic odontogenic tumor, only dentinoid production.

F: Female; M: Male; NA: Not available.

Table 2 Main data of 21 cases reported of ameloblastic fibrodentinosarcoma/ameloblastic fibro-odontosarcoma in the literature

Case	Ref.	Sex/age	Location	Mineralized tissues	Preexisting tumor	Progression
1	Villa[79]	F/20 yr	Posterior mandible	Enamel	Yes (NA)	Recurrence
2	Forman and Garret[80]	M/17 yr	Posterior mandible	Dentin and enamel	No	No recurrence
3	Altini and Smith[81]	M/27 yr	Mandible	Dentin	No	NA
4	Takeda et al[32]	M/19 yr	Maxilla	Dentin	AF	Recurrence and death
5	Howell and Burkes[31]	F/18 yr	Posterior mandible	Dentin and enamel	AFO	Recurrence, metastasis and death
6	Howell and Burkes[31]	M/36 yr	Posterior mandible	Dentin	AFO	Recurrence
7	Altini et al[41]	M/25 yr	Mandible	Dentin	No	No recurrence
8	Takeda et al[33]	M/23 yr	Mandible	Dentin and enamel	No	Recurrence and death
9	Corominas-Villafañe et al[82]	M/12 yr	Mandible	NA	AF	No recurrence
10	Herzog et al[83]1	F/14 yr	Mandible	NA	AFO	NA
11	Bregni et al[25]	M/32 yr	Mandible	Dentin	No	NA
12	Muller et a[84]	M/83 yr	Mandible	Dentin and enamel	AFO	Recurrence
13	Zabolinejad et al[35]	M/4 mo	Maxillary sinus	Dentin	No	No recurrence
14	Mainenti et al[34]	F/12 yr	Mandible	Dentin and enamel	AFO	No recurrence
15	Wang et al[30]	F/45 yr	Posterior mandible	Dentin and enamel	No	No recurrence
16	Reiser et al[85]	F/6 yr	Mandible	Dentin and enamel	No	No recurrence
17	Khan et al[86]	F/17 yr	Mandible	NA	No	NA
18	Gatz et al et al[87]	F/14 yr	Maxilla	Dentin	AFO	Recurrence
19	Chen et al[88]	M/4 yr	Mandible	Dentin and enamel	No	No recurrence
20	Niu et al[89]	F/31 yr	Mandible	Dentin and enamel	No	No recurrence at 3 months, lost follow-up
21	Atarbashi-Moghadam et al[90]	F/32 yr	Mandible	Dentin	No	Recurrence and metastasis

¹Article in German, abstract in English.

F: Female; M: Male; AF: Ameloblastic fibroma; AFO: Ameloblastic fibro-odontoma; AFDS: Ameloblastic fibrodentinosarcoma; AFOS: Ameloblastic fibroodontosarcoma; NA: Not available.

Table 3 Main data of 9 cases reported of ameloblastic/odontogenic carcinosarcoma in the literature

Case	Ref.	Sex/age	Location	Preexisting tumor	Progression
1	Tanaka et al[91]	M/63	Maxilla	Malignant ameloblastoma	Recurrence, metastasis and death
2	Slama et al[92]1	F/26	Mandible	AF	Metastasis and death
3	Kunkel et al[3]	M/52	Mandible	No	Recurrence, metastasis and death
4	DeLair et al[93]	F/19	Mandible	AF	No recurrence
5	Chikosi et al[94]	F/9	Mandible	Ameloblastoma	Recurrence and death
6	Kim et al[4]	M/61	Mandible	No	No recurrence
7	Dos Santos et al[95]	M/42	Maxilla	No	Unknown
8	Soares et al[96]	M/22	Mandible	No	No recurrence
9	Soares et al[96]	F/19	Mandible	Rhabdomyosarcoma (parotid region)2	Post-surgical systemic infection and death

¹Article in French, abstract in English.

²Thirteen years before, treated with surgical resection followed by radiotherapy.

M: Male; F: Female; AF: Ameloblastic fibroma.