Basic Study
Copyright ©The Author(s) 2021.
World J Clin Oncol. Dec 24, 2021; 12(12): 1202-1214
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1202
Table 1 The characteristics of study group
Parameter
Number of cases
Age
< 6029 (32.58%)
≥ 6060 (67.42%)
Gender
Female29 (32.58%)
Male60 (67.42%)
Tumor diameter
< 5 cm18 (20.22%)
≥ 5 cm71 (79.78%)
Tumor localization
Upper 1/3 17 (19.10%)
Middle1/3 33 (37.08%)
Lower 1/3 16 (17.98%)
Whole stomach23 (25.84%)
Histological type
Adenocarcinoma54 (60.67%)
Adenocarcinoma mucinosum35 (39.33%)
Histological differentiation
Moderately differentiated25 (28.09%)
Poorly differentiated35 (39.33%)
Non differentiated29 (32.58%)
Depth of invasion
T16 (6.74%)
T27 (7.87%)
T366 (74.16%)
T410 (11.23%)
Lymph node metastasis
Absent17 (19.10%)
Present72 (80.90%)
Distant metastasis
Absent61 (68.54%)
Present28 (31.46%)
Blood vessel infiltration
Absent48 (84.21%)
Present9 (15.79%)
Lymphatic vessel infiltration
Absent21 (31.82%)
Present45 (68.18%)
Perineural infiltration
Absent28 (34.15%)
Present54 (65.85%)
Peritumoral inflammation
Absent42 (50.00%)
Present42 (50.00%)
Desmoplasia
Small55 (66.27%)
Large28 (33.73%)
Helicobacter pylori infection
Absent61 (73.49%)
Present22 (26.51%)
Lauren’s classification
Intestinal44 (55.00%)
Diffuse36 (45.00%)
Table 2 Correlation between clinical pathological parameters and tensin 4 protein expression
ParameterExpression of tensin 4 protein
aP value
Negative
Positive
Age0.666
< 6014 (48.28%)15 (51.72%)
≥ 6026 (43.33%)34 (56.67%)
Gender0.182
Female16 (55.17%)13 (44.83%)
Male24 (40.00%)36 (60.00%)
Tumor diameter0.040
< 5 cm12 (66.67%)6 (33.33%)
≥ 5 cm28 (39.44%)43 (60.56%)
Tumor localization0.081
Upper 1/310 (58.82%)7 (41.18%)
Middle1/39 (27.27%)24 (72.73%)
Lower 1/39 (56.25%)7 (43.75%)
Whole stomach12 (52.17%)11 (47.83%)
Histological type0.023
Adenocarcinoma19 (35.19%)35 (64.81%)
Adenocarcinoma mucinosum21 (60.00%)14 (40.00%)
Histological differentiation0.002 (< 0.001)
Moderately differentiated5 (20.00%)20 (80.00%)
Poorly differentiated15 (42.86%)20 (57.14%)
Non differentiated20 (68.97%)9 (31.03%)
Depth of invasion0.208
T15 (83.33%)1 (16.67%)
T22 (28.57%)5 (71.43%)
T328 (42.42%)38 (57.58%)
T45 (50.00%)5 (50.00%)
Lymph node metastasis0.071
Absent11 (64.71%)6 (35.29%)
Present29 (40.28%)43 (59.72%)
Distant metastasis0.794
Absent28 (45.90%)33 (54.10%)
Present12 (42.86%)16 (57.14%)
Blood vessel infiltration0.980
Absent21 (43.75%)27 (56.25%)
Present4 (44.44%)5 (55.56%)
Lymphatic vessel infiltration0.358
Absent10 (47.62%)11 (52.38%)
Present16 (35.56%)29 (64.44%)
Perineural infiltration0.628
Absent13 (46.43%)15 (53.57%)
Present22 (40.74%)32 (59.26%)
Peritumoral inflammation0.453
Absent19 (46.34%)22 (53.66%)
Present16 (38.10%)26 (61.90%)
Desmoplasia0.710
Small24 (43.64%)31 (56.36%)
Large11 (39.29%)17 (60.71%)
Helicobacter pylori infection0.824
Absent26 (42.62%)35 (57.38%)
Present10 (45.45%)12 (54.55%)
Lauren’s classification0.020
Intestinal13 (29.55%)31 (70.45%)
Diffuse20 (55.56%)16 (44.44%)