Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives

doi:10.5306/wjco.v17.i3.115882

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 3

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (169)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

HTML

Figures (1-3)

Tables (1-2)

Sum=80

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=94

Publishing Process of This Article

Item

Count

Browse

Download

Sum=30

Mar 24, 2026 (publication date) through Mar 26, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Clinical Oncology

ISSN

2218-4333

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Oncol. Mar 24, 2026; 17(3): 115882
Published online Mar 24, 2026. doi: 10.5306/wjco.v17.i3.115882

Open in New Tab Full Size Figure Download Figure

Figure 1 Schematic of lactylation from lactate production to epigenetic and functional consequences. CoA: Coenzyme A; LDHA: Lactate dehydrogenase A.

Open in New Tab Full Size Figure Download Figure

Figure 2 Lactylation drives pancreatic cancer progression through multiple mechanisms. A: Lineage plasticity; B: Therapeutic resistance; C: Tumor stroma. BRCA1: Breast cancer type 1 susceptibility protein; CoA: Coenzyme A; LDHA: Lactate dehydrogenase A; MCT: Monocarboxylate transporter; MDSC: Myeloid-derived suppressor cells; PDAC: Pancreatic ductal adenocarcinoma; PD-1: Programmed death 1.

Open in New Tab Full Size Figure Download Figure

Figure 3 Therapeutic targeting strategies for lactylation in pancreatic ductal adenocarcinoma. ACSS2: Acyl-CoA synthetase short-chain family member 2; BET: Bromodomain and extra-terminal; CoA: Coenzyme A; LDHA: Lactate dehydrogenase A; MCT: Monocarboxylate transporter; PD-1: Programmed death 1.

Citation: Hawanga GD, Li ZX, Li MX, Zhang XL, Qian DH. Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives. World J Clin Oncol 2026; 17(3): 115882
URL: https://www.wjgnet.com/2218-4333/full/v17/i3/115882.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i3.115882