Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies

doi:10.5306/wjco.v17.i2.113674

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Feb 24, 2026 (publication date) through Feb 12, 2026

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 24, 2026; 17(2): 113674
Published online Feb 24, 2026. doi: 10.5306/wjco.v17.i2.113674

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Figure 1 Clinical application of immune-related mechanisms in digestive tract tumors with perineural invasion. This figure outlines the clinical application framework for immune-related prognosis and treatment in digestive tract tumors with perineural invasion. PNI: Perineural invasion; PD-1: Programmed death 1; PD-L1: Programmed death ligand 1; TILs: Tumor-infiltrating lymphocytes; MSI: Microsatellite instability; CAR-T: Chimeric antigen receptor T-cell; CTLA-4: Cytotoxic T lymphocyte-associated protein 4; CRC: Colorectal cancer.

Citation: Pang JY, Jin RY, Zhang HX, Zhang YH, Wei XY, Cao WB, Chen YX, Wang JL, Mo SJ. Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies. World J Clin Oncol 2026; 17(2): 113674
URL: https://www.wjgnet.com/2218-4333/full/v17/i2/113674.htm
DOI: https://dx.doi.org/10.5306/wjco.v17.i2.113674