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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 10, 2015; 6(6): 207-211
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.207
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.207
Microenvironment and endocrine resistance in breast cancer: Friend or foe?
Sol Recouvreux, Rocío Sampayo, María Inés Díaz Bessone, Marina Simian, Instituto de Oncología “Angel H. Roffo”, San Martín 5481, Buenos Aires, Argentina
Marina Simian, Escuela de Humanidades and Instituto de Nanosistemas, Universidad Nacional de San Martín, San Martín 1650, Buenos Aires, Argentina
Author contributions: Recouvreux S, Sampayo R and Díaz Besson MI contributed to the ideas and editing of the manuscript; Simian M wrote the editorial.
Supported by The Ministerio de Ciencia, Tecnología e Innovación Productiva, No. PICT2008-0325; and by CONICET.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marina Simian, PhD, Conicet Independent Researcher, CEDESI, Escuela de Humanidades and Instituto de Nanosistemas, Universidad Nacional de San Martín, 25 de mayo y Francia, San Martín 1650, Buenos Aires, Argentina. marina.simian@galuzzi.com
Telephone: +54-911-53856555 Fax: +54-11-40061500
Received: May 27, 2015
Peer-review started: May 28, 2015
First decision: August 4, 2015
Revised: September 7, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 10, 2015
Processing time: 196 Days and 18.5 Hours
Peer-review started: May 28, 2015
First decision: August 4, 2015
Revised: September 7, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 10, 2015
Processing time: 196 Days and 18.5 Hours
Core Tip
Core tip: Resistance to endocrine therapy in breast cancer is an important clinical problem that requires further insight to develop a solution. We here discuss a paradigm shift, where the interplay of the tumor cells with the microenvironment, and the role of cancer stem cells are discussed as key targets in the development of novel therapeutic strategies.