Wang H, He YL, Gao Y, Gao XR, Sun LY, Yan JC, Lu Q, Ni KW. Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China. World J Clin Oncol 2026; 17(8): 122421 [DOI: 10.5306/wjco.122421]
Corresponding Author of This Article
Kai-Wen Ni, PhD, Department of Infection Control, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. nkw721@zju.edu.cn
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Surgery
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research-article
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Wang H, He YL, Gao Y, Gao XR, Sun LY, Yan JC, Lu Q, Ni KW. Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China. World J Clin Oncol 2026; 17(8): 122421 [DOI: 10.5306/wjco.122421]
World J Clin Oncol. Aug 24, 2026; 17(8): 122421 Published online Aug 24, 2026. doi: 10.5306/wjco.122421
Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China
Hong Wang, Yu-Lu He, Yin Gao, Xing-Rong Gao, Li-Yuan Sun, Ji-Cheng Yan, Qun Lu, Kai-Wen Ni
Hong Wang, Yu-Lu He, Yin Gao, Xing-Rong Gao, Li-Yuan Sun, Ji-Cheng Yan, Qun Lu, Kai-Wen Ni, Department of Infection Control, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Wang H drafted manuscript; Wang H, Yan JC, Lu Q, and Ni KW designed the study; He YL, Gao Y, Gao XR, and Sun LY assisted with data collection and preparation; Yan JC, Lu Q, and Ni KW supervised the project and provided critical revision of manuscript; and all authors reviewed and approved the final version of the manuscript.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by the National Natural Science Foundation of China, No. 72504249.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine, approval No. (2026) 0381.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Kai-Wen Ni, PhD, Department of Infection Control, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. nkw721@zju.edu.cn
Received: April 20, 2026 Revised: June 30, 2026 Accepted: July 28, 2026 Published online: August 24, 2026 Processing time: 128 Days and 17.7 Hours
Core Tip
Core Tip: This disease-specific case-control study is among the first to systematically evaluate preoperative host physiologic reserve indices - including the modified frailty index, nutritional risk index, neutrophil-to-lymphocyte ratio, and prognostic nutritional index - as predictors of surgical site infection following meningioma resection in a Chinese neurosurgical cohort. Using precisely measured operative time (skin incision to wound closure) and Least Absolute Shrinkage and Selection Operator-informed multivariable modeling, we identified a 3.04-hour operative threshold beyond which surgical site infection risk increases 5.7-fold, and established preoperative neutrophil-to-lymphocyte ratio as an independent immune-nutritional predictor. These findings provide clinically actionable criteria for prospective risk stratification and targeted perioperative optimization.
