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World J Clin Oncol. Apr 24, 2026; 17(4): 119059
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.119059
Published online Apr 24, 2026. doi: 10.5306/wjco.v17.i4.119059
Clinicopathological disparities and prognostic implications of palpable vs non-palpable breast cancer: Toward precision multi-modal early screening strategies
Yu-Tong Han, Department of Neurology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Yue-Chuan Jiao, Chang Qiao, Hao-Wei Li, Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, Hebei Province, China
De-Hui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine, Hebei Province Hospital of Chinese Medicine, Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang 050000, Hebei Province, China
Co-first authors: Yu-Tong Han and Yue-Chuan Jiao.
Author contributions: Han YT and Jiao YC participated in manuscript writing, editing, and literature review, and they contributed equally to this manuscript and are co-first authors; Jiao YC prepared the figures for the manuscript; Qiao C and Li HW performed data collection and organization; Li DH conceived the overall study concept and outline, supervised the research process, and critically revised the manuscript. All authors have read and approved the final submitted version.
Supported by the Natural Science Foundation of Hebei Province, No. H2024423105; 2023 Government Funded Project of the Outstanding Talents Training Program in Clinical Medicine, No. ZF2023165; Key Research and Development Projects of Hebei Province, No. 18277731D; Hebei Provincial Administration of Traditional Chinese Medicine, Scientific Research Project, No. 2023045 and No. 2024023; Hebei Institute of Traditional Chinese Medicine Pharmaceutical Preparation Industry Technology Special Project, No. YJY2024006; and Scientific Research Project of Health Commission of Hebei Province, No. 20220962 and No. 20240282.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: De-Hui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine, Hebei Province Hospital of Chinese Medicine, Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, No. 389 Zhongshan East Road, Chang’an District, Shijiazhuang 050000, Hebei Province, China.
Received: January 19, 2026
Revised: February 5, 2026
Accepted: March 18, 2026
Published online: April 24, 2026
Processing time: 93 Days and 22.8 Hours
Revised: February 5, 2026
Accepted: March 18, 2026
Published online: April 24, 2026
Processing time: 93 Days and 22.8 Hours
Core Tip
Core Tip: This paper focuses on the differences between palpable and non-palpable tumors in breast cancer screening. The former is more invasive and early screening is crucial for improving prognosis. Multiple combined technologies, risk stratification screening, and the concept of “preventing disease before it occurs” can optimize the prevention and control effect.