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World J Clin Oncol. Aug 24, 2025; 16(8): 108906
Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.108906
Current advances in neuroendocrine neoplasms of the colon and rectum
Yun-Bin Ma, Zhi-Jie Wang
Yun-Bin Ma, The First Surgical Department, Hebei Medical University Yiling Hospital, Shijiazhuang 050000, Hebei Province, China
Zhi-Jie Wang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing 100142, China
Author contributions: Wang ZJ designed the study and reviewed the article; Ma YB searched the literature and drafted the article.
Supported by Science Foundation of Peking University Cancer Hospital, No. ZY202411.
Conflict-of-interest statement: The authors have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jie Wang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. 1459046932@qq.com
Received: April 28, 2025
Revised: May 28, 2025
Accepted: July 10, 2025
Published online: August 24, 2025
Processing time: 117 Days and 8.7 Hours
Core Tip

Core Tip: Colorectal neuroendocrine neoplasms represent a rare and highly heterogeneous group of tumors that are demonstrating increased detection rates. Due to their low incidence, difficulties in case collection and sample acquisition have led to slow progress in both clinical and basic research, thus resulting in a lack of standardized international guidelines and consensus on their treatment. We have reviewed and summarized recent research developments in this field, with an aim of providing readers with a comprehensive understanding of the current state of research and inspiring future studies.