Updates in the diagnosis and management of ductal adenocarcinoma of the pancreas

doi:10.5306/wjco.v16.i6.105601

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World Journal of Clinical Oncology

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World J Clin Oncol. Jun 24, 2025; 16(6): 105601
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.105601

Updates in the diagnosis and management of ductal adenocarcinoma of the pancreas

Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis

Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis, The 2^nd Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece

Author contributions: Pavlidis TE designed research, contributed new analytic tools; Pavlidis TE and Galanis IN analyzed data, review and approved the paper; Pavlidis ET performed research, analyzed data, review and wrote the article.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Theodoros E Pavlidis, MD, PhD, Professor, The 2^nd Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr

Received: January 30, 2025
Revised: April 8, 2025
Accepted: May 13, 2025
Published online: June 24, 2025
Processing time: 141 Days and 20.3 Hours

Core Tip

Core Tip: Pancreatic ductal adenocarcinoma is an aggressive malignancy with a delayed diagnosis and poor prognosis. The newest diagnostic tools and proper management are crucial for determining survival. The current approach must be multidisciplinary and individualized. Surgical resection alone is not enough; it must be accompanied by other novel therapeutic modalities, such as chemotherapy, radiotherapy, targeted gene therapy, immunotherapy and vaccines.