Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 24, 2025; 16(11): 111527
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111527
Published online Nov 24, 2025. doi: 10.5306/wjco.v16.i11.111527
Primary testicular diffuse large B-cell lymphoma with gonadal vein tumor thrombus: A case report and review of the literature
Yu-Zhi Zuo, Zhen Liang, Bo-Ju Pan, Wei-Gang Yan, Zhi-En Zhou, Department of Urology, Peking Union Medical College, Beijing 100005, China
Co-first authors: Yu-Zhi Zuo and Zhen Liang.
Co-corresponding authors: Wei-Gang Yan and Zhi-En Zhou.
Author contributions: Zuo YZ and Liang Z contributed equally to this work as co–first authors. Zuo YZ took primary responsibility for study conception and design, performed comprehensive collection of clinical data, drafted the initial manuscript, conducted literature review, integrated the case findings into the scientific context, and contributed to the preparation of figures and tables; Liang Z assisted in study design, managed the acquisition and organization of clinical and laboratory data, performed statistical and descriptive analyses, participated in drafting substantial sections of the manuscript, and provided critical revisions to improve clarity and scientific rigor. Yan WG and Zhou ZE contributed equally to this work as co–corresponding authors. Yan WG provided overall supervision of the project, guided the clinical interpretation of the case, critically revised the manuscript for intellectual content, coordinated communication among the research team, and ensured methodological accuracy; Zhou ZE was responsible for methodological guidance.
Informed consent statement: Written informed consent was obtained from the patient for publication of anonymized clinical data and images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Gang Yan, Professor, Department of Urology, Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100005, China.
Received: July 3, 2025
Revised: August 2, 2025
Accepted: October 10, 2025
Published online: November 24, 2025
Processing time: 142 Days and 18.1 Hours
Revised: August 2, 2025
Accepted: October 10, 2025
Published online: November 24, 2025
Processing time: 142 Days and 18.1 Hours
Core Tip
Core Tip: This is the first reported case of primary testicular diffuse large B-cell lymphoma presenting with a gonadal vein tumor thrombus, a manifestation previously unrecognized in this malignancy. The case underscores the pivotal role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in detecting rare vascular involvement and guiding staging. It also highlights the importance of a multidisciplinary approach in managing advanced-stage primary testicular lymphoma, which remains a rare but aggressive disease with distinct diagnostic and therapeutic challenges.