Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2024; 15(8): 1002-1020
Published online Aug 24, 2024. doi: 10.5306/wjco.v15.i8.1002
Biomarkers associated with immune-related adverse events induced by immune checkpoint inhibitors
An-Jie Guo, Qing-Yuan Deng, Pan Dong, Lian Zhou, Lei Shi
An-Jie Guo, Qing-Yuan Deng, Pan Dong, Lei Shi, School of Life Sciences, Chongqing University, Chongqing 400044, China
Lian Zhou, Head and Neck Cancer Center, Chongqing University Cancer Hospital, Chongqing 400000, China
Co-first authors: An-Jie Guo and Qing-Yuan Deng.
Co-corresponding authors: Lian Zhou and Lei Shi.
Author contributions: Guo AJ, Zhou L and Shi L participated in the design of the study, prepared table, figure and wrote the manuscript; Deng QY and Dong P performed some analysis and revised the manuscript. All authors read and approved the final manuscript.
Supported by The Fundamental Research Funds for the Central Universities, No. 2019CDYGYB024; The National Natural Science Foundation of China, No. 31300726; and The Chongqing Primary and Middle School Innovation Talent Training Project, No. CY220113.
Conflict-of-interest statement: The authors declare no competing or financial interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian Zhou, PhD, Attending Doctor, Head and Neck Cancer Center, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400000, China. zhoulianeve@163.com.
Received: January 8, 2024
Revised: May 13, 2024
Accepted: June 21, 2024
Published online: August 24, 2024
Processing time: 220 Days and 22.8 Hours
Core Tip

Core tip: The development of effective biomarkers for precise immune-related adverse events (irAEs) prediction and diagnosis is urgently needed. Therefore, a comprehensive review of current studies on irAEs biomarkers is essential. This review encompasses major irAEs and provides an overview of existing biomarkers for prediction, diagnosis, and prognosis. Additionally, it explores diverse approaches for identifying novel, reliable biomarkers, including machine learning, single-cell RNA sequencing, multiomics analysis, and gut microbiota assessment. Lastly, the review delves into the mechanisms underlying irAEs to enhance comprehension and guide the prediction, diagnosis, and management of these events.