Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2024; 15(7): 867-894
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.867
Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer
Jing-Yu Chen, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Gang Chen, Wen Zou
Jing-Yu Chen, Jian-Di Li, Zhi-Guang Huang, Gang Chen, Wen Zou, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Rong-Quan He, Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: He RQ, Huang ZG, Chen G, and Zou W designed the paper; Chen JY and Li JD performed literature and dataset screening, conducted bibliometric statistics, and carried out all computational analyses, including mRNA and protein expression, prognosis and signaling pathways; Chen JY, Li JD, Huang ZG, and Zou W constructed the figures and tables; Chen JY and Li JD wrote the draft; He RQ, Huang ZG, Chen G, and Zou W corrected the draft; and all authors have read and approved the final manuscript.
Supported by the Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project, No. Z-A20220530.
Conflict-of-interest statement: All the authors declare no competing financial interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen Zou, MM, Doctor, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. pathologyzw@sr.gxmu.edu.cn
Received: February 8, 2024
Revised: May 27, 2024
Accepted: June 24, 2024
Published online: July 24, 2024
Processing time: 159 Days and 0.2 Hours
Core Tip

Core Tip: The expression of phosphoglycerate kinase 1 (PGK1) in breast cancer (BC) was shown to be both a research hotspot and frontier of BC research. PGK1 mRNA levels were significantly higher in triple-negative BC (TNBC) than in non-cancerous breast tissue. Within the population with BC, PGK1 mRNA expression levels were distinctly upregulated in TNBC compared with non-TNBC. Recurrence-free survival was markedly lower in the PGK1-high-expression than the PGK1-low-expression group. PGK1 has a significant role in promoting TNBC through metabolism and HIF-1 signaling pathways.