Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. May 24, 2024; 15(5): 653-663
Published online May 24, 2024. doi: 10.5306/wjco.v15.i5.653
In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori
Rafaela Viana Vieira, Gabrielle Caroline Peiter, Fabrício Freire de Melo, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira
Rafaela Viana Vieira, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira, Universidade Federal do Paraná, Campus Toledo, Toledo 85919-899, Brazil
Gabrielle Caroline Peiter, Universidade Tecnológica Federal do Paraná, Campus Toledo, Paraná 85902-490, Brazil
Fabrício Freire de Melo, Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde-Campus Anísio Teixeira, Vitória da Conquista 45029-094, Brazil
Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira, Universidade Federal do Paraná-Setor Palotina, Programa de Pós-graduação em Biotecnologia, Palotina 85950-000, Brazil
Author contributions: Peiter GC performed the in silico experiments and analysis; Vieira RV and Teixeira KN interpreted the data and wrote the manuscript; Zarpelon-Schutz AC, de Melo FF and Teixeira KN performed the critical analysis of the results and coordinated the study; all authors approved the final version of the manuscript.
Institutional review board statement: Institutional review board declares awareness of the study and states that neither humans nor animals were involved in the research.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kádima Nayara Teixeira, PhD, Professor, Universidade Federal do Paraná, Campus Toledo, Max Planck 3796, Toledo 85919-899, Brazil. kadimateixeira@ufpr.br
Received: December 15, 2023
Revised: April 1, 2024
Accepted: April 18, 2024
Published online: May 24, 2024
Processing time: 157 Days and 13.1 Hours
Core Tip

Core Tip: Commonly, studies on the effects of medicinal plants on Helicobacter pylori (H. pylori) infection assess the antimicrobial activity of these plants. However, in this study, the authors conducted a prospective in silico analysis of the activity of certain phenolic compounds from plants used to treat H. pylori infection on stomach cells affected by CagA, aiming to prevent or block the oncogenic differentiation of these cells.