©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2023; 14(2): 40-68
Published online Feb 24, 2023. doi: 10.5306/wjco.v14.i2.40
Published online Feb 24, 2023. doi: 10.5306/wjco.v14.i2.40
Hereditary cancer syndromes
Evgeny N Imyanitov, Ekaterina S Kuligina, Anna P Sokolenko, Evgeny N Suspitsin, Grigoriy A Yanus, Aglaya G Iyevleva, Alexandr O Ivantsov, Svetlana N Aleksakhina, Department of Tumor Growth Biology, N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia
Evgeny N Imyanitov, Ekaterina S Kuligina, Anna P Sokolenko, Evgeny N Suspitsin, Grigoriy A Yanus, Aglaya G Iyevleva, Alexandr O Ivantsov, Svetlana N Aleksakhina, Department of Clinical Genetics, St.-Petersburg Pediatric Medical University, St.-Petersburg 194100, Russia
Author contributions: Imyanitov EN and Kuligina ES wrote the article draft; Kuligina ES prepared the illustration; Sokolenko AP, Suspitsin EN, Yanus GA, Iyevleva AG, Ivantsov AO, Aleksakhina SN acquired the literature data and analyzed the results; All authors approved the final version of the article.
Supported by The Russian Science Foundation , No. 17-75-30027 .
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Evgeny N Imyanitov, DSc, Professor, Department of Tumor Growth Biology, N.N. Petrov Institute of Oncology, Pesochny, Leningradskaya Str. 68, St.-Petersburg 197758, Russia. evgeny@imyanitov.spb.ru
Received: November 17, 2022
Peer-review started: November 17, 2022
First decision: November 30, 2022
Revised: December 9, 2022
Accepted: February 14, 2023
Article in press: February 14, 2023
Published online: February 24, 2023
Processing time: 95 Days and 18.3 Hours
Peer-review started: November 17, 2022
First decision: November 30, 2022
Revised: December 9, 2022
Accepted: February 14, 2023
Article in press: February 14, 2023
Published online: February 24, 2023
Processing time: 95 Days and 18.3 Hours
Core Tip
Core Tip: There are many reviews describing particular types of hereditary cancer syndromes (HCSs) (e.g., hereditary breast-ovarian cancer, Lynch syndrome, Li-Fraumeni syndrome, etc.). However, for the last 15-20 years there were no publications providing a general overview on familial cancers. Our paper describes mechanisms underlying genetic cancer predisposition, lists major types of HCSs, and comments on therapeutic advances in the management of hereditary tumors.