Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2022; 13(12): 980-983
Published online Dec 24, 2022. doi: 10.5306/wjco.v13.i12.980
Circulating tumour DNA in gastrointestinal cancer in clinical practice: Just a dream or maybe not?
Andrea Pretta, Eleonora Lai, Clelia Donisi, Dario Spanu, Pina Ziranu, Valeria Pusceddu, Marco Puzzoni, Elena Massa, Mario Scartozzi
Andrea Pretta, Eleonora Lai, Clelia Donisi, Dario Spanu, Pina Ziranu, Valeria Pusceddu, Marco Puzzoni, Elena Massa, Mario Scartozzi, Medical Oncology Unit, University Hospital and University of Cagliari, Monserrato 09042, Cagliari, Italy
Author contributions: Pretta A, Lai E, Donisi C, Spanu D, Ziranu P, Pusceddu V, Puzzoni M, Massa E, and Scartozzi M wrote and edited the manuscript.
Conflict-of-interest statement: Eleonora Lai has received advisory board and consultant fees from AstraZeneca and MSD. Mario Scartozzi has received consultant, advisory board and speakers’ bureau fees from Amgen, Sanofi, MSD, EISAI, Merck, Bayer.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eleonora Lai, MD, PhD, Staff Physician, Medical Oncology Unit, University Hospital and University of Cagliari, SS 554, km 4,500, bivio per Sestu, Monserrato 09042, Cagliari, Italy. eleonora.lai@unica.it
Received: August 18, 2022
Peer-review started: August 18, 2022
First decision: September 5, 2022
Revised: September 16, 2022
Accepted: November 21, 2022
Article in press: November 21, 2022
Published online: December 24, 2022
Processing time: 117 Days and 17.5 Hours
Core Tip

Core Tip: Circulating tumor DNA is a promising tool in the era of precision medicine, with several potential applications in the entire management of gastrointestinal malignancies. Further evidence is needed to assess in which setting liquid biopsy might have a greater impact in clinical practice.