Multidisciplinary treatment of soft tissue sarcomas: An update

doi:10.5306/wjco.v11.i4.180

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Apr 24, 2020 (publication date) through Mar 3, 2026

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Apr 24, 2020; 11(4): 180-189
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.180

Multidisciplinary treatment of soft tissue sarcomas: An update

Jorge Gómez, Panagiotis Tsagozis

Jorge Gómez, Department of Orthopedic Surgery, Clínica Universidad de Navarra, University of Navarra, Pamplona 31008, Spain

Panagiotis Tsagozis, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm 17176, Sweden

Panagiotis Tsagozis, Muskuloskeletal Tumour Service, Karolinska University Hospital, Stockholm 17176, Sweden

Author contributions: Gómez J performed the literature review and analysis, and manuscript writing; Tsagozis P revised and edited the manuscript.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Corresponding author: Jorge Gómez, MD, Surgeon, Surgical Oncologist, Department of Orthopedic Surgery, Clínica Universidad de Navarra, University of Navarra, Pío XII Avenue, Nº36, Pamplona 31008, Spain. jgomeza@unav.es

Received: December 28, 2019
Peer-review started: December 28, 2019
First decision: February 20, 2020
Revised: March 13, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 24, 2020
Processing time: 115 Days and 12.8 Hours

Core Tip

Core tip: This report provides an updated view of the diagnosis, treatment, and future perspectives on the management of patients with soft tissue sarcomas. Recent advances include new magnetic resonance imaging sequences such as diffusion-weighted imaging and magnetic resonance imaging radiomics, which can better assess tumor extension and estimate tumor grade. Detection of circulating genetic material (liquid biopsy) and next-generation sequencing are powerful techniques that may reveal potential therapeutic targets. Novel chemotherapeutic regimens have entered clinical praxis and can change the outcome of patients with metastatic disease. Advances in radiotherapy have helped decrease local adverse effects and sustain good local disease control.