Lazăr DC, Avram MF, Romoșan I, Văcariu V, Goldiș A, Cornianu M. Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management. World J Clin Oncol 2019; 10(3): 110-135 [PMID: 30949442 DOI: 10.5306/wjco.v10.i3.110]
Corresponding Author of This Article
Mihaela Flavia Avram, MD, PhD, Assistant Professor, Doctor, Surgeon, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Piata Eftimie Murgu No. 2, Timisoara 300041, Romania. avram.mihaela@umft.ro
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Mar 24, 2019; 10(3): 110-135 Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.110
Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management
Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Violetta Văcariu, Adrian Goldiș, Mărioara Cornianu
Daniela Cornelia Lazăr, Ioan Romoșan, Violetta Văcariu, Department of Internal Medicine I, University Medical Clinic, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Romania
Mihaela Flavia Avram, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Romania
Adrian Goldiș, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Romania
Mărioara Cornianu, Department of Pathology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara 300041, Romania
Author contributions: All the authors contributed equally to this work.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mihaela Flavia Avram, MD, PhD, Assistant Professor, Doctor, Surgeon, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Piata Eftimie Murgu No. 2, Timisoara 300041, Romania. avram.mihaela@umft.ro
Telephone: +40-256-220484 Fax: +40-256-220484
Received: January 13, 2019 Peer-review started: January 14, 2019 First decision: January 26, 2019 Revised: February 23, 2019 Accepted: March 12, 2019 Article in press: March 12, 2019 Published online: March 24, 2019 Processing time: 68 Days and 13.5 Hours
Core Tip
Core tip: Primary malignant vascular tumors of the liver are rare mesenchymal tumors, most commonly detected incidentally using modern imaging techniques. They have variable clinical and imaging features, histology, immunohistochemistry, and molecular findings; therefore, their diagnosis may be difficult. Surgery represents the mainstay of treatment. Hepatic angiosarcoma has a dismal outcome and represents a contraindication for liver transplantation. Development of novel antiangiogenic and other molecular targeted treatments are needed to improve the patient outcome. This paper provides an overview of this group of tumors based on the most recent literature data, encompassing modern information regarding diagnostic challenges, prognostic factors and perspective therapeutic approaches.
