Mechanisms and potential applications of COPS6 in pan-cancer therapy

Abstract

The COP9 signalosome subunit 6 (COPS6) is abnormally overexpressed in many malignancies, yet its precise role in carcinogenesis is unknown. To gain a better understanding of COPS6's role, the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns, prognostic value, gene mutations, immune infiltration, correlation analysis, and functional enrichment assessment. Results showed that COPS6 was highly correlated with prognosis, immune cell infiltration level, tumor mutation burden, and microsatellite instability in patients with a range of tumor types. This suggests that COPS6 may be a potential target for cancer treatment. Overall, this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.

Keywords: COPS6; Biomarker; Tumor mutational burden; Immune infiltration; Prognostic analysis

Core Tip: COPS6 expression is often increased in malignancies, and this is associated with a poor prognosis, suggesting that it could be a potential biomarker for tumors. However, the exact role of COPS6 in different types of tumors is still unknown. This research seeks to investigate the expression of COPS6 in various tumor tissues, its prognostic value, mutations in the gene, and the correlation between expression levels and immune infiltration with different types of immune cells.