TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells

doi:10.5306/wjco.v15.i2.175

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World Journal of Clinical Oncology

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World J Clin Oncol. Feb 24, 2024; 15(2): 175-177
Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.175

TM9SF1 is implicated in promoting the proliferation and invasion of bladder cancer cells

Shu-Qing Zhou, Lian-Xiang Luo

Shu-Qing Zhou, The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China

Lian-Xiang Luo, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China

Author contributions: Luo LX conceived and designed the editorial; Zhou SQ wrote the editorial; Luo LX reviewed the paper and provided comments; All authors read and approved the final manuscript.

Conflict-of-interest statement: All the authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Corresponding author: Lian-Xiang Luo, PhD, Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 East Wenming Road, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn

Received: December 9, 2023
Peer-review started: December 9, 2023
First decision: December 18, 2023
Revised: December 27, 2023
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: February 24, 2024
Processing time: 72 Days and 17.7 Hours

Abstract

Zhuo et al looked into the part of transmembrane 9 superfamily member 1 (TM9SF1) in bladder cancer (BC), and evaluated if it can be used as a therapeutic target. They created a permanent BC cell line and tested the effects of TM9SF1 overexpression and suppression on BC cell growth, movement, invasion, and cell cycle advancement. Their results show that TM9SF1 can boost the growth, movement, and invasion of BC cells and their access into the G2/M stage of the cell cycle. This research gives a novel direction and concept for targeted therapy of BC.

Keywords: Bladder cancer; TM9SF1; Cell proliferation; Migration; Invasion; TM9SF1 overexpression; TM9SF1 silencing inhibits

Core Tip: The transmembrane 9 superfamily member (TM9SF) TM9SF family's biological function has not been investigated yet. However, some studies have suggested that its expression could be associated with the emergence and progression of tumors. This article used various experimental methods, such as CCK8, wound healing test, transwell test, and flow cytometry, to explore the effect of TM9SF1 on the biological behavior of bladder cancer (BC), in order to offer a novel approach for the treatment of BC.