Zhang L, Chen ZY, Wei XX, Li JD, Chen G. What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade? World J Clin Oncol 2024; 15(1): 145-158 [PMID: 38292666 DOI: 10.5306/wjco.v15.i1.145]
Corresponding Author of This Article
Gang Chen, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jan 24, 2024; 15(1): 145-158 Published online Jan 24, 2024. doi: 10.5306/wjco.v15.i1.145
What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?
Lu Zhang, Zu-Yuan Chen, Xiao-Xian Wei, Jian-Di Li, Gang Chen
Lu Zhang, Zu-Yuan Chen, Xiao-Xian Wei, Jian-Di Li, Gang Chen, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhang L and Chen G conceived and designed the study. Zhang L, Chen ZY, Wei XX and Li JD searched the publications from Web of Science and decided which paper to be included, analyzed the data and made all the graphs; Zhang L drafted the manuscript; Chen G revised the manuscript.
Supported byGuangxi Zhuang Autonomous Region Health Commission Self-Financed Scientific Research Project, No. Z20201174; Innovation Project of Guangxi Graduate Education, No. YCBZ2023110; Guangxi Higher Education Undergraduate Teaching Reform Project, No. 2022JGA146; Guangxi Educational Science Planning Key Project, No. 2022ZJY2791; and Guangxi Medical High-level Key Talents Training "139" Program (2020).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Chen, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn
Received: October 22, 2023 Peer-review started: October 22, 2023 First decision: November 23, 2023 Revised: December 8, 2023 Accepted: December 28, 2023 Article in press: December 28, 2023 Published online: January 24, 2024 Processing time: 92 Days and 11.8 Hours
Abstract
BACKGROUND
Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies.
AIM
To make a comprehensive analysis of recent studies concerning miRNAs in HCC.
METHODS
All relevant publications were retrieved from the Web of Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace software were used to visually analyze the distribution by time, countries, institutions, journals, and authors, as well as the keywords, burst keywords and thematic map.
RESULTS
A total of 9426 publications on this topic were found worldwide. According to the keywords analysis, we found that the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the early years (2013–2017), “microRNA expression”, “gene expression”, “expression profile”, “functional polymorphism”, “circulating microRNA”, “susceptibility” and “mir 21” started to attract attention. In the latest phase (2018–2022), the hot topics turned to “sorafenib resistance”, “tumor microenvironment” and so on.
CONCLUSION
This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis. The hotspots in this field focus on miRNAs expression level, effects, and mechanisms on the biological behavior of HCC. The frontiers turned to sorafenib resistance, tumor microenvironment and so on.
Core Tip: The main objective of this work is to systematically analyse the recent research concerning microRNAs (miRNAs) in hepatocellular carcinoma (HCC). Annual publications provided an overview of the trends in this area, while distribution by countries, institutions, journals, and authors analysis were outstandingly representative and provided some cooperation situation information. According to the keywords analysis, the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the latest phase (2018–2022), the hot topics turned to “sorafenib resistance”, “tumor microenvironment” and so on.
