Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation

doi:10.4292/wjgpt.v14.i2.4

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Mar 5, 2023 (publication date) through Nov 3, 2025

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Mar 5, 2023; 14(2): 4-21
Published online Mar 5, 2023. doi: 10.4292/wjgpt.v14.i2.4

Table 1 Concentration of 5-hydroxytryptamine and vasoactive intestinal peptide in each group of mice

Groups (n = 8)	5-HT (ng/mL)	VIP (ng/mL)
Control	66.83 ± 4.50	14.64 ± 2.08
STC Model	53.48 ± 4.23^b	30.73 ± 3.70^b
PRU	67.69 ± 5.00^d	18.18 ± 1.92^d
CA-low	65.31 ± 4.44^d	19.28 ± 1.30^d
CA-high	66.00 ± 5.93^d	19.31 ± 1.75^d

^bP < 0.01 versus the control group.

^dP < 0.01 versus the slow transit constipation model group.

5-HT: 5-hydroxytryptamine; CA: Cinnamic acid; PRU: Prucalopride; VIP: Vasoactive intestinal peptide; STC: Slow transit constipation.

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Citation: Jiang JG, Luo Q, Li SS, Tan TY, Xiong K, Yang T, Xiao TB. Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation. World J Gastrointest Pharmacol Ther 2023; 14(2): 4-21
URL: https://www.wjgnet.com/2150-5349/full/v14/i2/4.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v14.i2.4