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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Mar 5, 2023; 14(2): 4-21
Published online Mar 5, 2023. doi: 10.4292/wjgpt.v14.i2.4
Published online Mar 5, 2023. doi: 10.4292/wjgpt.v14.i2.4
Cinnamic acid regulates the intestinal microbiome and short-chain fatty acids to treat slow transit constipation
Jin-Guang Jiang, Qian Luo, Department of Colorectal and Anal Surgery, Suqian Hospital of Traditional Chinese Medicine, Suqian 223800, Jiangsu Province, China
Shuang-Shuang Li, Tian-Ying Tan, Kai Xiong, College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou Province, China
Tao Yang, Tian-Bao Xiao, Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou Province, China
Author contributions: Jiang JG and Luo Q conceived the project and wrote the manuscript; Luo Q performed the central part of the experiments and analyzed data, with contributions from Li SS, Tan TY, and Xiong K; Yang T and Xiao TB participated in the experimental design and manuscript draft preparation and revision; All authors read and approved the final manuscript.
Supported by the "333 Scientific Project" of Jiangsu Province in 2020 , No. BRA2020237 ; and the Science and Technology Project of Suqian , Jiangsu Province in 2020, No. Z2020057.
Institutional animal care and use committee statement: All animal procedures were conducted in accordance with guidelines for laboratory animal care after approval by the Ethics Committee of Suqian Hospital of Traditional Chinese Medicine.
Conflict-of-interest statement: All authors of this manuscript state that they do not have any conflict of interests, and there is nothing to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Bao Xiao, MD, Doctor, Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Guiyang 550000, Guizhou Province, China.
Received: October 15, 2022
Peer-review started: October 15, 2022
First decision: January 3, 2023
Revised: January 10, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: March 5, 2023
Processing time: 139 Days and 2.6 Hours
Peer-review started: October 15, 2022
First decision: January 3, 2023
Revised: January 10, 2023
Accepted: February 21, 2023
Article in press: February 21, 2023
Published online: March 5, 2023
Processing time: 139 Days and 2.6 Hours
Core Tip
Core Tip: Studies on the gut microbiome and its metabolites are increasingly in slow transit constipation (STC). In this study, we found that Cinnamic acid (CA) improved and treated STC effectively by ameliorating intestinal mucosa's histopathological performance and secretory function in STC mice induced by loperamide, with alpha and beta diversity significantly decreased. Meanwhile, CA ameliorated the composition and abundance of the intestinal microbiome.