©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Dec 13, 2018; 9(7): 63-68
Published online Dec 13, 2018. doi: 10.4292/wjgpt.v9.i7.63
Published online Dec 13, 2018. doi: 10.4292/wjgpt.v9.i7.63
Potassium-competitive acid blockers - are they the next generation of proton pump inhibitors?
Prashanth Rawla, Department of Internal Medicine, SOVAH Health, Martinsville, VA 24112, United States
Tagore Sunkara, Andrew Ofosu, Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Clinical Affiliate of The Mount Sinai Hospital, New York, NY 11201, United States
Vinaya Gaduputi, Division of Gastroenterology, SBH Health System, Bronx, NY 10457, United States
Author contributions: Rawla P, Sunkara T and Ofosu A participated in the conception and design of this study; Rawla P, Sunkara T, Ofosu A and Gaduputi V participated equally in the analysis, interpretation, drafting, critical revisions and final approval of the article.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
Correspondence to: Prashanth Rawla, MD, Doctor, Department of Internal Medicine/Hospitalist, SOVAH Health, 320 Hospital Dr, Martinsville, VA 24112, United States. rawlap@gmail.com
Telephone: +1-276-6667200 Fax: +1-276-6667394
Received: August 27, 2018
Peer-review started: August 27, 2018
First decision: October 8, 2018
Revised: October 24, 2018
Accepted: November 26, 2018
Article in press: November 26, 2018
Published online: December 13, 2018
Processing time: 108 Days and 6.7 Hours
Peer-review started: August 27, 2018
First decision: October 8, 2018
Revised: October 24, 2018
Accepted: November 26, 2018
Article in press: November 26, 2018
Published online: December 13, 2018
Processing time: 108 Days and 6.7 Hours
Core Tip
Core tip: There have been tremendous changes in the treatment of acid-related diseases. In this rapidly evolving field, novel drugs such as potassium-competitive acid blockers (P-CABs) show promising potential. This review aims to provide a perspective on this new class of drugs by summarizing the mechanism of action, therapeutic benefits, adverse effects and approval status of various P-CABs in the market.