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World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 412-415
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.412
Chinese Helicobacter pylori vaccine: Solution for an old challenge?
Amin Talebi Bezmin Abadi, Yeong Yeh Lee
Amin Talebi Bezmin Abadi, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran
Yeong Yeh Lee, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
Author contributions: Talebi Bezmin Abadi A wrote the primary draft; Lee YY provided new modification for new version and both authors agreed on final version of the manuscript.
Conflict-of-interest statement: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amin Talebi Bezmin Abadi, PhD, Assistant Professor, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran. amin.talebi@modares.ac.ir
Telephone: +98-21-82884883 Fax: +98-21-82884883
Received: March 16, 2016
Peer-review started: March 18, 2016
First decision: April 5, 2016
Revised: April 9, 2016
Accepted: May 17, 2016
Article in press: May 27, 2016
Published online: August 6, 2016
Processing time: 138 Days and 9 Hours
Core Tip

Core tip:Helicobacter pylori (H. pylori) remains the most prevalent gastric infection. One of the main questionable aspects of H. pylori is its high resistance to most of prescribed antibiotics and lack of useful vaccines. Vaccine may be the best solution to the above problem but there are many challenges in producing such an effective therapeutic vaccine. That will be ideal that Chinese vaccine removes the need for bicarbonate administration because of its adverse side effects. Taking together, it is the first time that such a protective H. pylori vaccine is introduced to the world for high risk individuals.