Review
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World J Gastrointest Pharmacol Ther. Nov 6, 2014; 5(4): 209-217
Published online Nov 6, 2014. doi: 10.4292/wjgpt.v5.i4.209
Protein kinases are potential targets to treat inflammatory bowel disease
Lei Yang, Yutao Yan
Lei Yang, Yutao Yan, School of Medicine, Hangzhou Normal University, Hangzhou 310036, Zhejiang Province, China
Author contributions: Yang L contributed mainly to the revised version of this paper; Yan Y is responsible for designing and writing this paper.
Supported by The Program for Zhejiang Leading Team of Science and Technology Innovation, No. 2011R50021
Correspondence to: Yutao Yan, MD, PhD, School of Medicine, Hangzhou Normal University, 16 Xue Lin Street, Hangzhou 310036, Zhejiang Province, China. yutaoyan@yahoo.com
Telephone: +86-571-28867302 Fax: +86-571-28865626
Received: December 1, 2013
Revised: April 5, 2014
Accepted: July 27, 2014
Published online: November 6, 2014
Processing time: 346 Days and 22 Hours
Core Tip

Core tip: The roles of protein kinases in the pathogenesis and intervention of inflammatory bowel diseases (IBD) are emerging. In this article, we will review the specific roles of different protein kinases in the pathogenesis of IBD, classify these protein kinases into different categories based on their fundamental functions in IBD, and describe substantial new mechanistic insights into the pathogenesis of IBD, highlighting protein kinases as potential intervention targets against IBD.