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World J Gastrointest Pharmacol Ther. Aug 6, 2013; 4(3): 41-46
Published online Aug 6, 2013. doi: 10.4292/wjgpt.v4.i3.41
Published online Aug 6, 2013. doi: 10.4292/wjgpt.v4.i3.41
Inflammatory bowel disease: An archetype disorder of outer environment sensor systems
Giovanni C Actis, Floriano Rosina, Division of Gastro-Hepatology, Ospedale Gradenigo, 10153 Torino, Italy
Author contributions: Actis GC designed the study and drafted the paper; Rosina F chose and checked the references, and critically reviewed the final version to give his final approval.
Correspondence to: Giovanni C Actis, MD, Division of Gastro-Hepatology, Ospedale Gradenigo, Corso Regina 10, 10153 Torino, Italy. actis_g@libero.it
Telephone: +39-11- 8151250 Fax: +39-11- 8151388
Received: February 2, 2013
Revised: May 15, 2013
Accepted: June 5, 2013
Published online: August 6, 2013
Processing time: 179 Days and 17.8 Hours
Revised: May 15, 2013
Accepted: June 5, 2013
Published online: August 6, 2013
Processing time: 179 Days and 17.8 Hours
Core Tip
Core tip: With its extended mucosal surface in contact with the environment, an overly reactive lymphoid tissue underneath, and an extraordinarily abundant metagenomic flora, the gut is in the position to play a central role in the pathogenesis of both its core disorders (inflammatory bowel disease) and remote autoinflammatory or immunopathic diseases. The IBDs have been listed as a “barrier organ dysfunction”. We hereby focus on psoriasis, a barrier organ dysfunction which is often co-morbid with IBD, sharing with it microbial receptor genetic polymorphisms, and response to therapy. This comprehensive mindset shall boost science and drive our medical choices for immunoinflammatory pathology.