Loktionov A. Current approaches to disease severity and therapy effectiveness assessment in patients with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2026; 17(2): 116608 [DOI: 10.4292/wjgpt.v17.i2.116608]
Corresponding Author of This Article
Alexandre Loktionov, MD, PhD, Director, DiagNodus Ltd, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. alex.loktionov@diagnodus.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Review
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World Journal of Gastrointestinal Pharmacology and Therapeutics
ISSN
2150-5349
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Loktionov A. Current approaches to disease severity and therapy effectiveness assessment in patients with inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2026; 17(2): 116608 [DOI: 10.4292/wjgpt.v17.i2.116608]
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 116608 Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.116608
Current approaches to disease severity and therapy effectiveness assessment in patients with inflammatory bowel disease
Alexandre Loktionov
Alexandre Loktionov, DiagNodus Ltd, Cambridge CB4 0WS, United Kingdom
Author contributions: Loktionov A is responsible for all work related to the preparation of this review paper; Loktionov A has designed paper structure, performed literature search, contributed figures and tables, analysed literature data and wrote the paper.
Conflict-of-interest statement: Loktionov A reports personal fees from DiagNodus Ltd, outside the submitted work.
Corresponding author: Alexandre Loktionov, MD, PhD, Director, DiagNodus Ltd, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. alex.loktionov@diagnodus.com
Received: November 17, 2025 Revised: December 4, 2025 Accepted: February 9, 2026 Published online: June 5, 2026 Processing time: 193 Days and 8.3 Hours
Core Tip
Core Tip: Inflammatory bowel disease patients need continuous lifetime monitoring of disease activity and effects of therapeutic interventions. This review considers a wide range of approaches currently applied for this purpose. The reviewed modalities comprise clinical criteria, endoscopy, cross-sectional imaging, detection of biomarkers in body fluids and feces, gut microbiome analysis, and application of modern technologies, such as multi-omics and artificial intelligence. Artificial intelligence-driven integration of abundant information provided by a range of diagnostic and analytical approaches outlined in this review may help in transforming the current ‘one-size-fits-all’ inflammatory bowel disease treatment concept into a truly personalized model of disease care.
