Rakesh K Kochhar, DM, Professor, Department of Gastroenterology, Paras Hospital, Paras Hospital Road, Sector-22, Panchkula 134109, Haryana, India. dr_kochhar@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. Jun 5, 2026; 17(2): 114292 Published online Jun 5, 2026. doi: 10.4292/wjgpt.v17.i2.114292
Beyond gluten-free diet: Novel therapeutic frontiers in celiac disease armamentarium
Sandeep K Mundhra, Rakesh K Kochhar
Sandeep K Mundhra, Department of Gastroenterology, Geetanjali Medical College and Hospital, Udaipur 313001, Rājasthān, India
Rakesh K Kochhar, Department of Gastroenterology, Paras Hospital, Panchkula 134109, Haryana, India
Rakesh K Kochhar, Department of Gastroenterology, National Institute of Medical Sciences, Jaipur 303121, Rājasthān, India
Author contributions: Mundhra SK and Kochhar RK designed the overall concept and outline of the manuscript; Mundhra SK contributed to the literature review, writing and editing of the manuscript; Kochhar R supervised the literature search and writing, provided intellectual input and critically revised the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Rakesh K Kochhar, DM, Professor, Department of Gastroenterology, Paras Hospital, Paras Hospital Road, Sector-22, Panchkula 134109, Haryana, India. dr_kochhar@hotmail.com
Received: September 16, 2025 Revised: December 1, 2025 Accepted: February 3, 2026 Published online: June 5, 2026 Processing time: 253 Days and 22.3 Hours
Core Tip
Core Tip: Celiac disease is managed with a gluten-free diet, which is difficult to sustain and often fails to achieve full mucosal recovery. Advances in disease pathogenesis have led to novel therapies, including gluten-detoxifying enzymes, gluten-sequestering polymers, barrier stabilizers, tissue transglutaminase-2 inhibitors, human leukocyte antigen-DQ antagonists, cytokine-directed biologics, and tolerance-inducing strategies such as nanoparticle-based therapies. This review summarizes the current therapeutic pipeline, discusses the challenges of translating emerging therapies into routine practice, and highlights how future management is likely to evolve towards personalized, multimodal approaches that integrate dietary management with safe and effective adjunctive therapies.
