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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 112615
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112615
Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.112615
Acid peptic disorder compass: An Indian expert consensus on comprehensive management
Saroj Kant Sinha, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Rakesh Kochhar, Department of Gastro Sciences, Paras Health, Panchkula 134109, Haryana, India
KS Somasekhar Rao, Department of Gastroenterology, Yashoda Hospital, Hyderabad 500082, India
Dawesh Yadav, Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
Sujay Ray, Department of Gastroenterology, RG Kar Medical College and Hospital, Kolkata 700004, India
Aniruddha Pratap Singh, Department of Gastroenterology, Asian Institute of Gastroenterology Hospitals, Hyderabad 500029, India
Pradeepta Kumar Sethy, Department of Gastroenterology, Medica Superspecialty Hospital, Kolkata 700099, India
Ramit Mahajan, Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana 141001, India
D Viswanath Reddy, Department of Gastroenterology, Yashoda Hospital, Secunderabad 500003, India
Vivek Mohan Sharma, Department of Gastroenterology, Narayana Health - Rabindranath Tagore Hospital, Kolkata 700099, India
Antriksh Kumar, Department of Gastroenterology, Manipal Hospitals, Ranchi 834001, India
Amit Mishra, Department of Gastroenterology, Teerthankar Mahaveer Medical College and Hospital, Moradabad 244001, India
Shubham Jain, Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxman Nair Charitable Hospital, Mumbai 400008, Maharashtra, India
Onkar C Swami, Dinesh Patil, Medical Services Department, Alembic Pharmaceuticals Limited, Mumbai 400099, Maharashtra, India
Author contributions: Sinha SK, Kochhar R, Rao KSS, Yadav D, Ray S, Singh AP, Sethy PK, Mahajan R, Reddy DV, Sharma VM, Kumar A, Mishra A, Jain S, Swami OC, and Patil D contributed equally to the concept and design of the manuscript and approved the final version of the manuscript.
Supported by Alembic Pharmaceuticals Limited, Mumbai, Maharashtra, India.
Conflict-of-interest statement: Swami OC reports grants from Alembic Pharmaceuticals Ltd. India, during the conduct of the study; other from Alembic Pharmaceuticals Ltd. India, outside the submitted work. Swami OC and Patil D are full-time employees of Alembic Pharmaceuticals Limited, India, which actively markets vonoprazan, rabeprazole, dexlansoprazole, and sodium alginate antacid suspension. Other authors do not have any conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Onkar C Swami, MD, Medical Services Department, Alembic Pharmaceuticals Limited, Prime Corporate Park, Behind ITC Grand Maratha Sheraton, Sahar Road, Andheri East, Mumbai 400099, Maharashtra, India. onkar.swami@alembic.co.in
Received: August 4, 2025
Revised: September 25, 2025
Accepted: November 25, 2025
Published online: March 5, 2026
Processing time: 193 Days and 22.6 Hours
Revised: September 25, 2025
Accepted: November 25, 2025
Published online: March 5, 2026
Processing time: 193 Days and 22.6 Hours
Core Tip
Core Tip: Overlapping mechanisms in gastroesophageal reflux disease, peptic ulcer, and functional dyspepsia often hinder accurate symptom-based diagnosis. In India, easy access to over-the-counter proton pump inhibitors has fuelled self-diagnosis and prolonged unsupervised use, which reduces treatment efficacy and increases risks of infections and nutrient deficiencies. To address this, a task force of 13 gastroenterologists under the Society for Clinical Gastroenterology reviewed evidence and developed 20 expert consensus statements. Through literature review and discussion, they proposed the acid peptic disorders 360° compass algorithm for distinguishing symptoms and guiding rational acid-suppressive therapy. This algorithm aims to improve timely diagnosis, treatment, and the patient’s quality of life.