Pal P, Kata P, Mateen MA, Ankam VK, Jha DL, Gupta R, Tandan M, Duvvur NR. Multimodality ultrasound in Crohn’s disease strictures. World J Gastrointest Pharmacol Ther 2026; 17(1): 111833 [DOI: 10.4292/wjgpt.v17.i1.111833]
Corresponding Author of This Article
Partha Pal, MD, FASGE, MRCP, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, 6-3-661 Red Rose Cafe Lane, Sangeet Nagar, Somajiguda, Hyderabad 500082, Telangāna, India. partha0123456789@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Pharmacol Ther. Mar 5, 2026; 17(1): 111833 Published online Mar 5, 2026. doi: 10.4292/wjgpt.v17.i1.111833
Multimodality ultrasound in Crohn’s disease strictures
Partha Pal, Priyaranjan Kata, Mohammad Abdul Mateen, Vamsi Krishna Ankam, Deepak Lalan Jha, Rajesh Gupta, Manu Tandan, Nageshwar Reddy Duvvur
Partha Pal, Vamsi Krishna Ankam, Deepak Lalan Jha, Rajesh Gupta, Manu Tandan, Nageshwar Reddy Duvvur, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad 500082, Telangāna, India
Priyaranjan Kata, Department of Medicine, MedStar St. Mary’s Hospital, Leonardtown, MD 20650, United States
Mohammad Abdul Mateen, Diagnostic Radiology and Imaging, Asian Institute of Gastroenterology, Hyderabad 500082, Telangāna, India
Co-first authors: Partha Pal and Priyaranjan Kata.
Author contributions: Pal P and Kata P contributed equally to this manuscript and are co-first authors; Pal P, Ankam VK, Gupta R, and Tandan M contributed to the literature search; Kata P and Jha DK contributed to critical manuscript review; Pal P conceptualized the work, wrote the first draft, and prepared the final manuscript; Kata P performed the first screening; Mateen MA resolved disagreements after screening; Ankam VK contributed to the manuscript review; Jha DK proofread the manuscript; Gupta R, Mateen MA, Tandan M, and Reddy DN contributed to the writing, provided intellectual input, and critically revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Partha Pal, MD, FASGE, MRCP, Department of Medical Gastroenterology, Asian Institute of Gastroenterology, 6-3-661 Red Rose Cafe Lane, Sangeet Nagar, Somajiguda, Hyderabad 500082, Telangāna, India. partha0123456789@gmail.com
Received: July 11, 2025 Revised: August 21, 2025 Accepted: January 6, 2026 Published online: March 5, 2026 Processing time: 216 Days and 4 Hours
Core Tip
Core Tip: Multimodal intestinal ultrasound - including contrast-enhanced ultrasound, small intestine contrast ultrasonography, and ultrasound-based elastography - offers a noninvasive, radiation-free, and accurate approach to characterize Crohn’s disease strictures. Small intestine contrast ultrasonography reliably detects strictures and disease extent with performance comparable to cross-sectional imaging. Contrast-enhanced ultrasound perfusion parameters such as peak enhancement and AUC help differentiate inflammation from fibrosis, especially when combined with elastography. Shear wave elastography provides quantitative stiffness assessment, with velocities > 2.5 m/second indicating fibrosis. These tools support precise stricture phenotyping and may guide tailored therapy and surgical decision-making.
