Vagus nerve neuromodulation: A promising method for treating gastrointestinal dysmotility

doi:10.4292/wjgpt.v16.i4.111266

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Dec 5, 2025 (publication date) through Mar 4, 2026

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 111266
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111266

Vagus nerve neuromodulation: A promising method for treating gastrointestinal dysmotility

Jie Liu

Jie Liu, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China

Author contributions: Liu J drafted the manuscript and critically revised the manuscript; the author read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Jie Liu, PhD, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com

Received: June 26, 2025
Revised: July 18, 2025
Accepted: September 1, 2025
Published online: December 5, 2025
Processing time: 162 Days and 9.9 Hours

Core Tip

Core Tip: The study by Zhang et al offers compelling mechanistic insights into how electroacupuncture at the stomach 36 (Zusanli) acupuncture point improves gastric dysmotility in diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. This work significantly advances the understanding of acupuncture’s neuromodulatory effects, providing a scientific foundation for non-pharmacological management of diabetic gastroparesis. The authors identified a peripheral-to-central pathway: Electroacupuncture at the stomach 36 activated cholinergic targets, specifically choline acetyltransferase and the alpha 7 nicotinic acetylcholine receptor. This activation initiated signal transmission through spinal afferents in the L4 to L6 segments of the spinal cord, which were then integrated within the nucleus tractus solitarius, resulting in vagal efferent modulation of gastric targets.