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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Dec 5, 2025; 16(4): 111073
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111073
Published online Dec 5, 2025. doi: 10.4292/wjgpt.v16.i4.111073
Metabolic syndrome after liver transplantation: A silent threat to long-term success
Shu-Yen Chan, Internal Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States
Junseo Lee, Marie Laryea, Jonathan Huang, Patrick Twohig, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY 14682, United States
Pratikshya Karki, Department of Public Health, University of Rochester Medical Center, Rochester, NY 14682, United States
Nicholas Lim, Department of Transplant Hepatology, University of Rochester Medical Center, Rochester, Rochester, NY 14682, United States
Author contributions: Chan SY, Lee J, Karki P, Laryea M, Huang J, Lim N, and Twohig P contributed equally to this work; Twohig P designed the study concepts and outline; Chan SY, Lee J, Karki P conducted the literature review and drafted the manuscript; Laryea M, Huang J, Lim N, and Twohig P made critical revisions; all authors prepared the draft and approved the submitted version.
Conflict-of-interest statement: The authors report no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Patrick Twohig, MD, Assistant Professor, FRCPC, Department of Gastroenterology and Hepatology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14682, United States. patrick_twohig@urmc.rochester.edu
Received: June 23, 2025
Revised: August 5, 2025
Accepted: November 10, 2025
Published online: December 5, 2025
Processing time: 166 Days and 7.5 Hours
Revised: August 5, 2025
Accepted: November 10, 2025
Published online: December 5, 2025
Processing time: 166 Days and 7.5 Hours
Core Tip
Core Tip: Metabolic syndrome (MetS) is increasingly recognized as a major contributor to morbidity and mortality after liver transplantation. This review highlights the pathophysiology, epidemiology, and clinical impact of post-transplant MetS. We also outline current strategies for screening, prevention, pharmacological treatment and surgical management.