Safety and efficacy of efruxifermin in metabolic dysfunction-associated steatohepatitis: A systematic review
Abul Bashar Mohammad Kamrul-Hasan, Sanja Borozan, Sweekruti Jena, Lakshmi Nagendra, Deep Dutta, Saptarshi Bhattacharya, Md Saiful Islam, Joseph M Pappachan
Abul Bashar Mohammad Kamrul-Hasan, Department of Endocrinology, Mymensingh Medical College, Mymensingh 2200, Bangladesh
Sanja Borozan, Department of Endocrinology, Clinical Centre of Montenegro, Podgorica 81000, Montenegro
Sanja Borozan, Faculty of Medicine, University of Montenegro, Podgorica 81000, Montenegro
Sweekruti Jena, Department of Endocrinology, Kalinga Hospital, Bhubaneshwar 751023, Odisha, India
Lakshmi Nagendra, Department of Endocrinology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore 570004, Karnataka, India
Deep Dutta, Department of Endocrinology, CEDAR Superspeciality Healthcare, Dwarka, New Delhi 110075, India
Saptarshi Bhattacharya, Department of Endocrinology, Indraprastha Apollo Hospitals, New Delhi 110076, India
Md Saiful Islam, Department of Hepatology, Bangladesh Medical University, Dhaka 1000, Bangladesh
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, Greater Manchester, United Kingdom
Joseph M Pappachan, Department of Endocrinology, Kasturba Medical College, Manipal and Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
Author contributions: Kamrul-Hasan ABM and Borozan S conceptualized and designed the study; Dutta D, Bhattacharya S, Islam MS, and Jena S performed the full-text review and data identification; Nagendra L, Dutta D and Islam MS evaluated the quality of the literature; Kamrul-Hasan ABM, Nagendra L and Pappachan JM collected and analyzed the data and drew the tables and figures; Borozan S and Pappachan JM adjudicated any disagreements; Kamrul-Hasan ABM, Borozan S and Pappachan JM wrote the draft; Nagendra L, Dutta D, Borozan S, Islam MS, Jena S, and reviewed and revised the manuscript; Kamrul-Hasan ABM and Pappachan JM were responsible for the integrity of the work as a whole; all author made contributions to the article and endorsed the submitted version.
Conflict-of-interest statement: The authors have no conflicts of interest to declare regarding this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Joseph M Pappachan, MD, MRCP, FRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, Oxford Road, Manchester M15 6BH, Greater Manchester, United Kingdom.
drpappachan@yahoo.co.in
Received: June 13, 2025
Revised: June 21, 2025
Accepted: July 15, 2025
Published online: September 5, 2025
Processing time: 83 Days and 24 Hours
