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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Sep 5, 2025; 16(3): 109046
Published online Sep 5, 2025. doi: 10.4292/wjgpt.v16.i3.109046
Published online Sep 5, 2025. doi: 10.4292/wjgpt.v16.i3.109046
Electroacupuncture alleviates symptoms and identifies a potential microbial biomarker in patients with constipation-predominant irritable bowel syndrome
Kiangyada Yaklai, Sriphat Medical Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Chanon Kunasol, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C Chattipakorn, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Muang 50200, Chiang Mai, Thailand
Chanon Kunasol, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C Chattipakorn, Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand
Kanokphong Suparan, Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Taned Chitapanarux, Department of Internal Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Sintip Pattanakuhar, Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Co-first authors: Kiangyada Yaklai and Chanon Kunasol.
Author contributions: Yaklai K performed the experiments, analyzed the data, and wrote the manuscript; Kunasol C, Suparan K, and Apaijai N performed the experiments and analyzed the data; Chitapanarux T, and Pattanakuhar S designed the study and edited the manuscript; Chattipakorn N designed the study, contributed to the discussion, and edited the manuscript; Chattipakorn SC designed the study, analyzed the data, contributed to the discussion, and edited and finalized the manuscript; All authors approved the final version of the manuscript.
Institutional review board statement: This study was approved by the Research Ethics Committee of the Faculty of Medicine, Chiang Mai University, Thailand (Study Code: No. FAM-256307774, Research No. 07774).
Clinical trial registration statement: This study registered at http://itmctr.ccebtcm.org.cn/en-US. The registration identification number is ITMCTR2023000067.
Informed consent statement: All study participants, or their legal guardians, provided written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement: The 16S rRNA gene sequencing data generated in this study have been deposited in the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) under the accession number PRJNA1264069. All microbiome analyses were conducted using QIIME 2 (version 2024.10), following standard workflows available at: https://docs.qiime2.org/2024.10/tutorials/. Analysis scripts and clinical metadata are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Siriporn C Chattipakorn, DDS, PhD, Professor, Cardiac Electrophysio
Received: April 29, 2025
Revised: May 23, 2025
Accepted: July 2, 2025
Published online: September 5, 2025
Processing time: 129 Days and 0.3 Hours
Revised: May 23, 2025
Accepted: July 2, 2025
Published online: September 5, 2025
Processing time: 129 Days and 0.3 Hours
Core Tip
Core Tip: Given the complex pathophysiology of irritable bowel syndrome (IBS), inconsistency of gut microbiota profiles, and the scarce evidence regarding constipation subtype, current treatments often focus on symptom management. Elec